Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients
Renal fibrosis remains an important cause of kidney allograft failure. The objective of this study was to evaluate the performance of serum human epididymis secretory protein 4 (HE4) as a biomarker for renal fibrosis in kidney transplant recipients. A total of 103 kidney transplantation patients wer...
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| Veröffentlicht in: | Clinica chimica acta 2018-08, Vol.483, p.216-221 |
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| container_title | Clinica chimica acta |
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| creator | Luo, Jinmei Wang, Fen Wan, Jianxin Ye, Zhuangjian Huang, Chumei Cai, Yuesu Liu, Min Wu, Ben-Quan Li, Laisheng |
| description | Renal fibrosis remains an important cause of kidney allograft failure. The objective of this study was to evaluate the performance of serum human epididymis secretory protein 4 (HE4) as a biomarker for renal fibrosis in kidney transplant recipients.
A total of 103 kidney transplantation patients were enrolled in this study, and serum HE4 concentrations were detected using the chemiluminescent microparticle immunoassay. Renal biopsy was carried out, and histological findings were assessed by immunohistochemistry.
Median serum HE4 concentrations were significantly increased in kidney transplant recipients (186.2 pmol/l, interquartile range [IQR] 125.6–300.2) compared with control subjects (34.3 pmol/l, IQR 30.4–42.3, p |
| doi_str_mv | 10.1016/j.cca.2018.05.006 |
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A total of 103 kidney transplantation patients were enrolled in this study, and serum HE4 concentrations were detected using the chemiluminescent microparticle immunoassay. Renal biopsy was carried out, and histological findings were assessed by immunohistochemistry.
Median serum HE4 concentrations were significantly increased in kidney transplant recipients (186.2 pmol/l, interquartile range [IQR] 125.6–300.2) compared with control subjects (34.3 pmol/l, IQR 30.4–42.3, p < 0.0001). Meanwhile, serum HE4 concentrations were significantly increased along with disease severity (p < 0.0001). In addition, we found serum HE4 concentrations to be strongly correlated with the severity of fibrosis (IF/TA 0, 1, 2, and 3: 114.3, 179.0, 197.8, and 467.8 pmol/l, respectively; p < 0.0001) and serum HE4 concentrations significantly correlated with HE4 tissue expression concentrations in renal biopsy.
Serum HE4 was increased in kidney transplant recipients with decreased kidney function and renal fibrosis and was correlated with the severity of the disease, suggesting that HE4 has the potential to be used as a novel clinical biomarker for evaluating kidney function and predicting renal fibrosis in kidney transplant recipients.
•Serum HE4 was elevated in kidney transplant recipients.•Serum HE4 associated with decreased kidney function.•Serum HE4 associated with renal fibrosis.•Serum HE4 could be a clinical biomarker for renal fibrosis in kidney transplant recipients.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2018.05.006</identifier><identifier>PMID: 29738696</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Biomarker ; Biomarkers - blood ; Diagnosis ; Female ; Fibrosis ; Fibrosis - diagnosis ; HE4 ; Humans ; Kidney Diseases - complications ; Kidney Diseases - pathology ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Male ; Middle Aged ; Proteins - analysis ; Transplant Recipients</subject><ispartof>Clinica chimica acta, 2018-08, Vol.483, p.216-221</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-c4b1605f534174dfd18d63d306b2ae1a146ddc840c12553f4ec7b9579250dcaa3</citedby><cites>FETCH-LOGICAL-c419t-c4b1605f534174dfd18d63d306b2ae1a146ddc840c12553f4ec7b9579250dcaa3</cites><orcidid>0000-0001-9336-8397</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2018.05.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29738696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Jinmei</creatorcontrib><creatorcontrib>Wang, Fen</creatorcontrib><creatorcontrib>Wan, Jianxin</creatorcontrib><creatorcontrib>Ye, Zhuangjian</creatorcontrib><creatorcontrib>Huang, Chumei</creatorcontrib><creatorcontrib>Cai, Yuesu</creatorcontrib><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Wu, Ben-Quan</creatorcontrib><creatorcontrib>Li, Laisheng</creatorcontrib><title>Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Renal fibrosis remains an important cause of kidney allograft failure. The objective of this study was to evaluate the performance of serum human epididymis secretory protein 4 (HE4) as a biomarker for renal fibrosis in kidney transplant recipients.
A total of 103 kidney transplantation patients were enrolled in this study, and serum HE4 concentrations were detected using the chemiluminescent microparticle immunoassay. Renal biopsy was carried out, and histological findings were assessed by immunohistochemistry.
Median serum HE4 concentrations were significantly increased in kidney transplant recipients (186.2 pmol/l, interquartile range [IQR] 125.6–300.2) compared with control subjects (34.3 pmol/l, IQR 30.4–42.3, p < 0.0001). Meanwhile, serum HE4 concentrations were significantly increased along with disease severity (p < 0.0001). In addition, we found serum HE4 concentrations to be strongly correlated with the severity of fibrosis (IF/TA 0, 1, 2, and 3: 114.3, 179.0, 197.8, and 467.8 pmol/l, respectively; p < 0.0001) and serum HE4 concentrations significantly correlated with HE4 tissue expression concentrations in renal biopsy.
Serum HE4 was increased in kidney transplant recipients with decreased kidney function and renal fibrosis and was correlated with the severity of the disease, suggesting that HE4 has the potential to be used as a novel clinical biomarker for evaluating kidney function and predicting renal fibrosis in kidney transplant recipients.
•Serum HE4 was elevated in kidney transplant recipients.•Serum HE4 associated with decreased kidney function.•Serum HE4 associated with renal fibrosis.•Serum HE4 could be a clinical biomarker for renal fibrosis in kidney transplant recipients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarker</subject><subject>Biomarkers - blood</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Fibrosis - diagnosis</subject><subject>HE4</subject><subject>Humans</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proteins - analysis</subject><subject>Transplant Recipients</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVIaLZJf0AvRcde1h1ZH7bpKYQmLQR6SHMWsjQm2qw_KsmB7a_vhE17zEVixDMveh_GPgqoBAjzZVd576oaRFuBrgDMCduItpFbqbr6lG0AoNu2XSvO2fucdzQqMOIdO6-7RramMxv25x7TOvLHdXQTxyWGGA5jzDyjT1jmdOBLmgvGiSvuMnd8oWkq0e15H-fRpSdMfB54womehtinOdM68U8xTHjgJbkpL3s3FVfiPBHo4xIpIl-ys8HtM354vS_Yw823X9fft3c_b39cX91tvRJdobMXBvSgpRKNCkMQbTAySDB97VA4oUwIvlXgRa21HBT6pu9009UagndOXrDPx1xq8nvFXCwV9LinP-G8ZluDNEQ3oAkVR9RTjZxwsEuKVPJgBdgX5XZnSbl9UW5BW1JOO59e49d-xPB_459jAr4eAaSSzxGTzZ4EeAyRZBQb5vhG_F9JCZPL</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Luo, Jinmei</creator><creator>Wang, Fen</creator><creator>Wan, Jianxin</creator><creator>Ye, Zhuangjian</creator><creator>Huang, Chumei</creator><creator>Cai, Yuesu</creator><creator>Liu, Min</creator><creator>Wu, Ben-Quan</creator><creator>Li, Laisheng</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9336-8397</orcidid></search><sort><creationdate>201808</creationdate><title>Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients</title><author>Luo, Jinmei ; Wang, Fen ; Wan, Jianxin ; Ye, Zhuangjian ; Huang, Chumei ; Cai, Yuesu ; Liu, Min ; Wu, Ben-Quan ; Li, Laisheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-c4b1605f534174dfd18d63d306b2ae1a146ddc840c12553f4ec7b9579250dcaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarker</topic><topic>Biomarkers - blood</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Fibrosis - diagnosis</topic><topic>HE4</topic><topic>Humans</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proteins - analysis</topic><topic>Transplant Recipients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Jinmei</creatorcontrib><creatorcontrib>Wang, Fen</creatorcontrib><creatorcontrib>Wan, Jianxin</creatorcontrib><creatorcontrib>Ye, Zhuangjian</creatorcontrib><creatorcontrib>Huang, Chumei</creatorcontrib><creatorcontrib>Cai, Yuesu</creatorcontrib><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Wu, Ben-Quan</creatorcontrib><creatorcontrib>Li, Laisheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Jinmei</au><au>Wang, Fen</au><au>Wan, Jianxin</au><au>Ye, Zhuangjian</au><au>Huang, Chumei</au><au>Cai, Yuesu</au><au>Liu, Min</au><au>Wu, Ben-Quan</au><au>Li, Laisheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2018-08</date><risdate>2018</risdate><volume>483</volume><spage>216</spage><epage>221</epage><pages>216-221</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Renal fibrosis remains an important cause of kidney allograft failure. The objective of this study was to evaluate the performance of serum human epididymis secretory protein 4 (HE4) as a biomarker for renal fibrosis in kidney transplant recipients.
A total of 103 kidney transplantation patients were enrolled in this study, and serum HE4 concentrations were detected using the chemiluminescent microparticle immunoassay. Renal biopsy was carried out, and histological findings were assessed by immunohistochemistry.
Median serum HE4 concentrations were significantly increased in kidney transplant recipients (186.2 pmol/l, interquartile range [IQR] 125.6–300.2) compared with control subjects (34.3 pmol/l, IQR 30.4–42.3, p < 0.0001). Meanwhile, serum HE4 concentrations were significantly increased along with disease severity (p < 0.0001). In addition, we found serum HE4 concentrations to be strongly correlated with the severity of fibrosis (IF/TA 0, 1, 2, and 3: 114.3, 179.0, 197.8, and 467.8 pmol/l, respectively; p < 0.0001) and serum HE4 concentrations significantly correlated with HE4 tissue expression concentrations in renal biopsy.
Serum HE4 was increased in kidney transplant recipients with decreased kidney function and renal fibrosis and was correlated with the severity of the disease, suggesting that HE4 has the potential to be used as a novel clinical biomarker for evaluating kidney function and predicting renal fibrosis in kidney transplant recipients.
•Serum HE4 was elevated in kidney transplant recipients.•Serum HE4 associated with decreased kidney function.•Serum HE4 associated with renal fibrosis.•Serum HE4 could be a clinical biomarker for renal fibrosis in kidney transplant recipients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29738696</pmid><doi>10.1016/j.cca.2018.05.006</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9336-8397</orcidid></addata></record> |
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| subjects | Adult Aged Biomarker Biomarkers - blood Diagnosis Female Fibrosis Fibrosis - diagnosis HE4 Humans Kidney Diseases - complications Kidney Diseases - pathology Kidney transplantation Kidney Transplantation - adverse effects Male Middle Aged Proteins - analysis Transplant Recipients |
| title | Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients |
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