Molecular dynamics-based model of VEGF-A and its heparin interactions

We present a computational model of the Vascular Endothelial Growth Factor (VEGF), an important regulator of blood vessels formation, which function is affected by its heparin interactions. Although structures of a receptor binding (RBD) and a heparin binding domain (HBD) of VEGF are known, there ar...

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Veröffentlicht in:	Journal of molecular graphics & modelling 2018-06, Vol.82, p.157-166
Hauptverfasser:	Uciechowska-Kaczmarzyk, Urszula, Babik, Sándor, Zsila, Ferenc, Bojarski, Krzysztof Kamil, Beke-Somfai, Tamás, Samsonov, Sergey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular dichroism spectroscopy Molecular docking Protein-glycosaminoglycan interactions Replica exchange molecular dynamics VEGF
Online-Zugang:	Volltext
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