Skewed megakaryopoiesis in human induced pluripotent stem cell‐derived haematopoietic progenitor cells harbouring calreticulin mutations

Summary Somatic mutations in the calreticulin (CALR) gene have been found in most patients with JAK2‐ and MPL‐unmutated Philadelphia chromosome‐negative myeloproliferative neoplasms (MPNs). It has recently been shown that mutant CALR constitutively activates the thrombopoietin receptor MPL and, thus...

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Veröffentlicht in:	British journal of haematology 2018-06, Vol.181 (6), p.791-802
Hauptverfasser:	Takei, Hiraku, Edahiro, Yoko, Mano, Shuichi, Masubuchi, Nami, Mizukami, Yoshihisa, Imai, Misa, Morishita, Soji, Misawa, Kyohei, Ochiai, Tomonori, Tsuneda, Satoshi, Endo, Hiroshi, Nakamura, Sou, Eto, Koji, Ohsaka, Akimichi, Araki, Marito, Komatsu, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	anagrelide Bone marrow Calreticulin Calreticulin - genetics Calreticulin - metabolism Cell Differentiation Chemical compounds Erythropoiesis Female GATA-1 protein GATA1 Transcription Factor - genetics GATA1 Transcription Factor - metabolism GATA2 Transcription Factor - genetics GATA2 Transcription Factor - metabolism Hematology Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Janus kinase 2 Male Megakaryocytes - cytology Megakaryocytes - metabolism megakaryopoiesis Mutation Myelopoiesis myeloproliferative neoplasm Philadelphia chromosome Pluripotency Progenitor cells Stem cells Thrombopoietin
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