Born to run: control of transcription elongation by RNA polymerase II

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an integral part of the implementation of gene expression programmes during development. In most metazoans, the majority of transcribed genes exhibit transient pausing of Pol II at promoter-proximal regions, and the...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2018-07, Vol.19 (7), p.464-478
Hauptverfasser:	Chen, Fei Xavier, Smith, Edwin R., Shilatifard, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/572 Adenosine diphosphate Biochemistry Biomedical and Life Sciences Cancer Cancer Research Cell Biology Developmental Biology DNA topoisomerase DNA-directed RNA polymerase Elongation Enhancers Gene expression Gene regulation Genes Genetic transcription Genomics Life Sciences Monosaccharides Poly(ADP-ribose) Poly(ADP-ribose) polymerase Review Article Ribonucleic acid Ribose RNA RNA polymerase RNA polymerase II Stem Cells Sugars Therapeutic targets Transcription elongation
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