A higher percentage of cells with 13q deletion predicts worse outcome in Chinese patients with chronic lymphocytic leukemia carrying isolated 13q deletion

Previous studies showed that, in chronic lymphocytic leukemia (CLL) patients with isolated 13q deletion (13q-), those carrying higher percentage of leukemic cells with 13q- had more aggressive diseases. However, the prognostic value of the percentage of leukemic cells with 13q- in Chinese CLL patien...

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Veröffentlicht in:	Annals of hematology 2018-09, Vol.97 (9), p.1663-1669
Hauptverfasser:	Miao, Yuqing, Miao, Yi, Shi, Ke, Sun, Qian, Zhao, Si-Shu, Xia, Yi, Qin, Shu-Chao, Qiu, Hai-Rong, Yang, Hui, Xu, Hao, Zhu, Hua-Yuan, Wu, Jia-Zhu, Wu, Wei, Cao, Lei, Wang, Li, Fan, Lei, Xu, Wei, Li, Jian-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Asian Continental Ancestry Group China - epidemiology Chromosome Deletion Chromosome Disorders - genetics Chromosome Disorders - mortality Chromosomes, Human, Pair 13 - genetics Disease-Free Survival Female Hematology Humans In Situ Hybridization, Fluorescence Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - mortality Male Medical prognosis Medicine Medicine & Public Health Middle Aged Oncology Original Article Survival Rate
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Zusammenfassung:	Previous studies showed that, in chronic lymphocytic leukemia (CLL) patients with isolated 13q deletion (13q-), those carrying higher percentage of leukemic cells with 13q- had more aggressive diseases. However, the prognostic value of the percentage of leukemic cells with 13q- in Chinese CLL patients with isolated 13q- remained to be determined. Using interphase fluorescence in situ hybridization (FISH), we identified 82 patients (25.4%) with isolated 13q deletion from a cohort of 323 untreated CLL patients. Among patients with isolated 13q deletion, cases of 13q- cells ≥ 80% (13q-H) had significantly shorter time to first treatment (TTT) than those of
ISSN:	0939-5555 1432-0584
DOI:	10.1007/s00277-018-3359-9