Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein in decompensated cirrhosis
Background and Aim An assay for Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA+‐M2BP) has been reported as a useful non‐invasive marker for the evaluation of the staging of fibrosis in several chronic liver diseases. However, available data on the effect of WFA+‐M2BP level...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2018-11, Vol.33 (11), p.1889-1896 |
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| creator | Uojima, Haruki Hidaka, Hisashi Tanaka, Yoshiaki Inoue, Tomoyoshi Onoue, Mie Wada, Naohisa Kubota, Kousuke Nakazawa, Takahide Shibuya, Akitaka Fujikawa, Tomoaki Nakayama, Tsuyoshi Yamanoue, Hiroki Sung, Ji Hyun Kako, Makoto Koizumi, Wasaburo |
| description | Background and Aim
An assay for Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA+‐M2BP) has been reported as a useful non‐invasive marker for the evaluation of the staging of fibrosis in several chronic liver diseases. However, available data on the effect of WFA+‐M2BP level in decompensated cirrhosis patients were limited. It is important that these investigations can validate the diagnostic utility of WFA+‐M2BP in the full range of patients with liver cirrhosis.
Methods
A multicenter study was conducted at five locations in Japan. A total of 207 patients with liver cirrhosis were enrolled in the present study. To determine whether or not the WFA+‐M2BP value was associated with a progression of fibrosis among cirrhosis, this study examined WFA+‐M2BP levels between patients with cirrhosis in the decompensated and compensated groups.
Results
The numbers and proportions of compensated and decompensated patients were 113 (54.6%) and 94 (45.4%), respectively. The average WFA+‐M2BP levels were 2.22 ± 1.61 in the compensated group and 6.91 ± 5.04 in the decompensated group. Significantly higher WFA+‐M2BP levels were observed in the decompensated group than those in the compensated group (P |
| doi_str_mv | 10.1111/jgh.14277 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2036203349</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2036203349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4197-534666ecf215e2088c0c9d8696e2fa31fa891fe446495b25ba3ffd39169fb7f83</originalsourceid><addsrcrecordid>eNp1kM9O3DAQxi1UxG63PfACKFIv9JDF_-LER7Tir0BcqHq0HGe861XiLHYC2huPwDPyJHVZ4FCpoxmNNPrNp08fQocEz0mqk_VyNSecluUemhLOcU5KLr6gKa5IkUtG5AR9jXGNMea4LA7QhMqSlUVFp6j-7eIAwenMtn1w9egbnenlsh0H551_fX7Z9NEN7hGy1dhpn91qk440q51vnF9mm9AP4HyWugHTdxvwUQ_QZMaFsEq_8Rvat7qN8P19z9Cv87P7xWV-c3dxtTi9yQ0nsswLxoUQYCwlBVBcVQYb2VRCCqBWM2J1JYkFzgWXRU2LWjNrGyaJkLYubcVm6Hinmyw9jBAH1blooG21h36MimIm0jAuE_rjH3Tdj8End4oSUmH5Bs7Qzx1lQh9jAKs2wXU6bBXB6m_wKgWv3oJP7NG74lh30HySH0kn4GQHPLkWtv9XUtcXlzvJP7bfjuM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2118096203</pqid></control><display><type>article</type><title>Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein in decompensated cirrhosis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Uojima, Haruki ; Hidaka, Hisashi ; Tanaka, Yoshiaki ; Inoue, Tomoyoshi ; Onoue, Mie ; Wada, Naohisa ; Kubota, Kousuke ; Nakazawa, Takahide ; Shibuya, Akitaka ; Fujikawa, Tomoaki ; Nakayama, Tsuyoshi ; Yamanoue, Hiroki ; Sung, Ji Hyun ; Kako, Makoto ; Koizumi, Wasaburo</creator><creatorcontrib>Uojima, Haruki ; Hidaka, Hisashi ; Tanaka, Yoshiaki ; Inoue, Tomoyoshi ; Onoue, Mie ; Wada, Naohisa ; Kubota, Kousuke ; Nakazawa, Takahide ; Shibuya, Akitaka ; Fujikawa, Tomoaki ; Nakayama, Tsuyoshi ; Yamanoue, Hiroki ; Sung, Ji Hyun ; Kako, Makoto ; Koizumi, Wasaburo</creatorcontrib><description>Background and Aim
An assay for Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA+‐M2BP) has been reported as a useful non‐invasive marker for the evaluation of the staging of fibrosis in several chronic liver diseases. However, available data on the effect of WFA+‐M2BP level in decompensated cirrhosis patients were limited. It is important that these investigations can validate the diagnostic utility of WFA+‐M2BP in the full range of patients with liver cirrhosis.
Methods
A multicenter study was conducted at five locations in Japan. A total of 207 patients with liver cirrhosis were enrolled in the present study. To determine whether or not the WFA+‐M2BP value was associated with a progression of fibrosis among cirrhosis, this study examined WFA+‐M2BP levels between patients with cirrhosis in the decompensated and compensated groups.
Results
The numbers and proportions of compensated and decompensated patients were 113 (54.6%) and 94 (45.4%), respectively. The average WFA+‐M2BP levels were 2.22 ± 1.61 in the compensated group and 6.91 ± 5.04 in the decompensated group. Significantly higher WFA+‐M2BP levels were observed in the decompensated group than those in the compensated group (P < 0.0001). The respective cut‐off index values for decompensated cirrhosis were estimated using receiver‐operating characteristic curves for WFA+‐M2BP levels. Using a cut‐off index value of 3.37 for WFA+‐M2BP, predicting decompensated cirrhosis had a sensitivity of 77.8% and a specificity of 86.7%.
Conclusions
WFA+‐M2BP values were higher in patients with decompensated liver cirrhosis.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.14277</identifier><identifier>PMID: 29737582</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Aged ; Antigens, Neoplasm - blood ; Biomarkers - blood ; Child‐Pugh score ; Chronic Disease ; Cirrhosis ; decompensated cirrhosis ; Disease Progression ; Female ; Fibrosis ; Humans ; Liver - pathology ; Liver cirrhosis ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - pathology ; Liver diseases ; liver fibrosis ; Male ; Membrane Glycoproteins - blood ; Middle Aged ; non‐invasive markers ; Plant Lectins - blood ; Receptors, N-Acetylglucosamine - blood ; Sensitivity and Specificity ; WFA+‐M2BP ; Wisteria floribunda</subject><ispartof>Journal of gastroenterology and hepatology, 2018-11, Vol.33 (11), p.1889-1896</ispartof><rights>2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd</rights><rights>2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4197-534666ecf215e2088c0c9d8696e2fa31fa891fe446495b25ba3ffd39169fb7f83</citedby><cites>FETCH-LOGICAL-c4197-534666ecf215e2088c0c9d8696e2fa31fa891fe446495b25ba3ffd39169fb7f83</cites><orcidid>0000-0003-1719-1352</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.14277$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.14277$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29737582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uojima, Haruki</creatorcontrib><creatorcontrib>Hidaka, Hisashi</creatorcontrib><creatorcontrib>Tanaka, Yoshiaki</creatorcontrib><creatorcontrib>Inoue, Tomoyoshi</creatorcontrib><creatorcontrib>Onoue, Mie</creatorcontrib><creatorcontrib>Wada, Naohisa</creatorcontrib><creatorcontrib>Kubota, Kousuke</creatorcontrib><creatorcontrib>Nakazawa, Takahide</creatorcontrib><creatorcontrib>Shibuya, Akitaka</creatorcontrib><creatorcontrib>Fujikawa, Tomoaki</creatorcontrib><creatorcontrib>Nakayama, Tsuyoshi</creatorcontrib><creatorcontrib>Yamanoue, Hiroki</creatorcontrib><creatorcontrib>Sung, Ji Hyun</creatorcontrib><creatorcontrib>Kako, Makoto</creatorcontrib><creatorcontrib>Koizumi, Wasaburo</creatorcontrib><title>Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein in decompensated cirrhosis</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
An assay for Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA+‐M2BP) has been reported as a useful non‐invasive marker for the evaluation of the staging of fibrosis in several chronic liver diseases. However, available data on the effect of WFA+‐M2BP level in decompensated cirrhosis patients were limited. It is important that these investigations can validate the diagnostic utility of WFA+‐M2BP in the full range of patients with liver cirrhosis.
Methods
A multicenter study was conducted at five locations in Japan. A total of 207 patients with liver cirrhosis were enrolled in the present study. To determine whether or not the WFA+‐M2BP value was associated with a progression of fibrosis among cirrhosis, this study examined WFA+‐M2BP levels between patients with cirrhosis in the decompensated and compensated groups.
Results
The numbers and proportions of compensated and decompensated patients were 113 (54.6%) and 94 (45.4%), respectively. The average WFA+‐M2BP levels were 2.22 ± 1.61 in the compensated group and 6.91 ± 5.04 in the decompensated group. Significantly higher WFA+‐M2BP levels were observed in the decompensated group than those in the compensated group (P < 0.0001). The respective cut‐off index values for decompensated cirrhosis were estimated using receiver‐operating characteristic curves for WFA+‐M2BP levels. Using a cut‐off index value of 3.37 for WFA+‐M2BP, predicting decompensated cirrhosis had a sensitivity of 77.8% and a specificity of 86.7%.
Conclusions
WFA+‐M2BP values were higher in patients with decompensated liver cirrhosis.</description><subject>Aged</subject><subject>Antigens, Neoplasm - blood</subject><subject>Biomarkers - blood</subject><subject>Child‐Pugh score</subject><subject>Chronic Disease</subject><subject>Cirrhosis</subject><subject>decompensated cirrhosis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver diseases</subject><subject>liver fibrosis</subject><subject>Male</subject><subject>Membrane Glycoproteins - blood</subject><subject>Middle Aged</subject><subject>non‐invasive markers</subject><subject>Plant Lectins - blood</subject><subject>Receptors, N-Acetylglucosamine - blood</subject><subject>Sensitivity and Specificity</subject><subject>WFA+‐M2BP</subject><subject>Wisteria floribunda</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9O3DAQxi1UxG63PfACKFIv9JDF_-LER7Tir0BcqHq0HGe861XiLHYC2huPwDPyJHVZ4FCpoxmNNPrNp08fQocEz0mqk_VyNSecluUemhLOcU5KLr6gKa5IkUtG5AR9jXGNMea4LA7QhMqSlUVFp6j-7eIAwenMtn1w9egbnenlsh0H551_fX7Z9NEN7hGy1dhpn91qk440q51vnF9mm9AP4HyWugHTdxvwUQ_QZMaFsEq_8Rvat7qN8P19z9Cv87P7xWV-c3dxtTi9yQ0nsswLxoUQYCwlBVBcVQYb2VRCCqBWM2J1JYkFzgWXRU2LWjNrGyaJkLYubcVm6Hinmyw9jBAH1blooG21h36MimIm0jAuE_rjH3Tdj8End4oSUmH5Bs7Qzx1lQh9jAKs2wXU6bBXB6m_wKgWv3oJP7NG74lh30HySH0kn4GQHPLkWtv9XUtcXlzvJP7bfjuM</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Uojima, Haruki</creator><creator>Hidaka, Hisashi</creator><creator>Tanaka, Yoshiaki</creator><creator>Inoue, Tomoyoshi</creator><creator>Onoue, Mie</creator><creator>Wada, Naohisa</creator><creator>Kubota, Kousuke</creator><creator>Nakazawa, Takahide</creator><creator>Shibuya, Akitaka</creator><creator>Fujikawa, Tomoaki</creator><creator>Nakayama, Tsuyoshi</creator><creator>Yamanoue, Hiroki</creator><creator>Sung, Ji Hyun</creator><creator>Kako, Makoto</creator><creator>Koizumi, Wasaburo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1719-1352</orcidid></search><sort><creationdate>201811</creationdate><title>Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein in decompensated cirrhosis</title><author>Uojima, Haruki ; Hidaka, Hisashi ; Tanaka, Yoshiaki ; Inoue, Tomoyoshi ; Onoue, Mie ; Wada, Naohisa ; Kubota, Kousuke ; Nakazawa, Takahide ; Shibuya, Akitaka ; Fujikawa, Tomoaki ; Nakayama, Tsuyoshi ; Yamanoue, Hiroki ; Sung, Ji Hyun ; Kako, Makoto ; Koizumi, Wasaburo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4197-534666ecf215e2088c0c9d8696e2fa31fa891fe446495b25ba3ffd39169fb7f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Antigens, Neoplasm - blood</topic><topic>Biomarkers - blood</topic><topic>Child‐Pugh score</topic><topic>Chronic Disease</topic><topic>Cirrhosis</topic><topic>decompensated cirrhosis</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver diseases</topic><topic>liver fibrosis</topic><topic>Male</topic><topic>Membrane Glycoproteins - blood</topic><topic>Middle Aged</topic><topic>non‐invasive markers</topic><topic>Plant Lectins - blood</topic><topic>Receptors, N-Acetylglucosamine - blood</topic><topic>Sensitivity and Specificity</topic><topic>WFA+‐M2BP</topic><topic>Wisteria floribunda</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uojima, Haruki</creatorcontrib><creatorcontrib>Hidaka, Hisashi</creatorcontrib><creatorcontrib>Tanaka, Yoshiaki</creatorcontrib><creatorcontrib>Inoue, Tomoyoshi</creatorcontrib><creatorcontrib>Onoue, Mie</creatorcontrib><creatorcontrib>Wada, Naohisa</creatorcontrib><creatorcontrib>Kubota, Kousuke</creatorcontrib><creatorcontrib>Nakazawa, Takahide</creatorcontrib><creatorcontrib>Shibuya, Akitaka</creatorcontrib><creatorcontrib>Fujikawa, Tomoaki</creatorcontrib><creatorcontrib>Nakayama, Tsuyoshi</creatorcontrib><creatorcontrib>Yamanoue, Hiroki</creatorcontrib><creatorcontrib>Sung, Ji Hyun</creatorcontrib><creatorcontrib>Kako, Makoto</creatorcontrib><creatorcontrib>Koizumi, Wasaburo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uojima, Haruki</au><au>Hidaka, Hisashi</au><au>Tanaka, Yoshiaki</au><au>Inoue, Tomoyoshi</au><au>Onoue, Mie</au><au>Wada, Naohisa</au><au>Kubota, Kousuke</au><au>Nakazawa, Takahide</au><au>Shibuya, Akitaka</au><au>Fujikawa, Tomoaki</au><au>Nakayama, Tsuyoshi</au><au>Yamanoue, Hiroki</au><au>Sung, Ji Hyun</au><au>Kako, Makoto</au><au>Koizumi, Wasaburo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein in decompensated cirrhosis</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2018-11</date><risdate>2018</risdate><volume>33</volume><issue>11</issue><spage>1889</spage><epage>1896</epage><pages>1889-1896</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
An assay for Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA+‐M2BP) has been reported as a useful non‐invasive marker for the evaluation of the staging of fibrosis in several chronic liver diseases. However, available data on the effect of WFA+‐M2BP level in decompensated cirrhosis patients were limited. It is important that these investigations can validate the diagnostic utility of WFA+‐M2BP in the full range of patients with liver cirrhosis.
Methods
A multicenter study was conducted at five locations in Japan. A total of 207 patients with liver cirrhosis were enrolled in the present study. To determine whether or not the WFA+‐M2BP value was associated with a progression of fibrosis among cirrhosis, this study examined WFA+‐M2BP levels between patients with cirrhosis in the decompensated and compensated groups.
Results
The numbers and proportions of compensated and decompensated patients were 113 (54.6%) and 94 (45.4%), respectively. The average WFA+‐M2BP levels were 2.22 ± 1.61 in the compensated group and 6.91 ± 5.04 in the decompensated group. Significantly higher WFA+‐M2BP levels were observed in the decompensated group than those in the compensated group (P < 0.0001). The respective cut‐off index values for decompensated cirrhosis were estimated using receiver‐operating characteristic curves for WFA+‐M2BP levels. Using a cut‐off index value of 3.37 for WFA+‐M2BP, predicting decompensated cirrhosis had a sensitivity of 77.8% and a specificity of 86.7%.
Conclusions
WFA+‐M2BP values were higher in patients with decompensated liver cirrhosis.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29737582</pmid><doi>10.1111/jgh.14277</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1719-1352</orcidid></addata></record> |
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| ispartof | Journal of gastroenterology and hepatology, 2018-11, Vol.33 (11), p.1889-1896 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Antigens, Neoplasm - blood Biomarkers - blood Child‐Pugh score Chronic Disease Cirrhosis decompensated cirrhosis Disease Progression Female Fibrosis Humans Liver - pathology Liver cirrhosis Liver Cirrhosis - diagnosis Liver Cirrhosis - pathology Liver diseases liver fibrosis Male Membrane Glycoproteins - blood Middle Aged non‐invasive markers Plant Lectins - blood Receptors, N-Acetylglucosamine - blood Sensitivity and Specificity WFA+‐M2BP Wisteria floribunda |
| title | Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein in decompensated cirrhosis |
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