Improved survival after LTx‐associated acute GVHD with mAb therapy targeting IL2RAb and soluble TNFAb: Single‐center experience and systematic review

Acute graft‐versus‐host disease (GVHD) after liver transplant (LTx) is a rare complication with a high mortality rate. Recently, monoclonal antibody (mAb) treatment, specifically with anti–interleukin 2 receptor antibodies (IL2RAb) and anti–tumor necrosis factor‐α antibodies (TNFAb), has gained incr...

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Veröffentlicht in:	American journal of transplantation 2018-12, Vol.18 (12), p.3007-3020
Hauptverfasser:	Minnee, R. C., Fieuws, S., Jochmans, I., Aerts, R., Sainz Barriga, M., Debaveye, Y., Maertens, J., Vandenberghe, P., Laleman, W., Merwe, S., Verslype, C., Cassiman, D., Ferdinande, P., Nevens, F., Pirenne, J., Monbaliu, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal - therapeutic use Case reports Clinical outcomes clinical research/practice complication Evidence-based medicine Female Follow-Up Studies Graft Rejection - drug therapy Graft Rejection - etiology Graft Rejection - mortality Graft Survival Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft vs Host Disease - mortality Graft-versus-host reaction graft‐versus‐host disease (GVHD) Humans Immunotherapy Interleukin 2 Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors Literature reviews Liver diseases Liver transplantation Liver Transplantation - adverse effects Liver Transplantation - mortality liver transplantation/hepatology Liver transplants Male Middle Aged Monoclonal antibodies Patients Postoperative Complications Prognosis Retrospective Studies Risk Factors Survival Survival Rate Systematic review Transplants & implants Tumor Necrosis Factor-alpha - antagonists & inhibitors
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