Application of DNA Machineries for the Barcode Patterned Detection of Genes or Proteins

The study introduces an analytical platform for the detection of genes or aptamer-ligand complexes by nucleic acid barcode patterns generated by DNA machineries. The DNA machineries consist of nucleic acid scaffolds that include specific recognition sites for the different genes or aptamer-ligand an...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-06, Vol.90 (11), p.6468-6476
Hauptverfasser:	Zhou, Zhixin, Luo, Guofeng, Wulf, Verena, Willner, Itamar
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Aptamers Aptamers, Nucleotide - analysis Aptamers, Nucleotide - genetics Base Sequence Biosensing Techniques - methods BRCA1 protein Chemistry Coordination compounds Cystic fibrosis Deoxyribonucleic acid DNA DNA - analysis DNA - genetics DNA polymerase Electrophoresis - methods Genes Humans Ligands Nicking endonuclease Nucleic acids Optical Imaging - methods p53 Protein Pattern Recognition, Automated - methods Proteins Proteins - analysis Proteins - genetics Scaffolds Strands Werner's syndrome Yield
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