Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry

Higher-order structure (HOS) characterization of therapeutic protein-drug conjugates for comprehensive assessment of conjugation-induced protein conformational changes is an important consideration in the biopharmaceutical industry to ensure proper behavior of protein therapeutics. In this study, co...

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Veröffentlicht in:	Journal of the American Society for Mass Spectrometry 2018-07, Vol.29 (7), p.1524-1531
Hauptverfasser:	Huang, Richard Y.-C., O’Neil, Steven R., Lipovšek, Daša, Chen, Guodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Bioinformatics Biotechnology Chemistry Chemistry and Materials Science Conjugation Deuterium Mass spectrometry Organic Chemistry Proteins Proteomics Research Article Scientific imaging Spectroscopy Structural analysis
Online-Zugang:	Volltext
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