Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates

•Complete multi-step protein conjugation process on liquid handling station.•Reagent removal by automated intermediate buffer exchange step.•Automated intermediate protein quantification with process feedback.•Case studies demonstrating efficiency and comparability. Antibody-drug conjugates (ADCs) f...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of biotechnology 2018-07, Vol.278, p.48-55
Hauptverfasser:	Andris, Sebastian, Wendeler, Michaela, Wang, Xiangyang, Hubbuch, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	ADC Antibody Automation Buffer exchange Conjugation High-Throughput
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!