Notch Signaling Regulates Microglial Activation and Inflammatory Reactions in a Rat Model of Temporal Lobe Epilepsy

The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subseque...

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Veröffentlicht in:	Neurochemical research 2018-06, Vol.43 (6), p.1269-1282
Hauptverfasser:	Wu, Lei, Li, Yushuang, Yu, Minhua, Yang, Fei, Tu, Mengqi, Xu, Haibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Chemical compounds Cytokines Epilepsy Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Hypoxia Immunofluorescence Immunohistochemistry Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Inflammatory response Inhibitors Male Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Neurochemistry Neurology Neurosciences Notch protein Original Paper Pharmacology Pilocarpine - toxicity Rats Rats, Sprague-Dawley Receptors, Notch - biosynthesis Rodents Secretase Signal Transduction - drug effects Signal Transduction - physiology Signaling Temporal lobe Western blotting
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