The contribution of cholesterol and epigenetic changes to the pathophysiology of breast cancer

[Display omitted] Cholesterol is an important risk factor of estrogen receptor positive breast cancer. 27 HC functions as an estrogen receptor agonist and contributes to ER positive breast cancer growth. 27Hc is linked to obesity and cholesterol- mediated breast cancer progression. Role of epigeneti...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2018-10, Vol.183, p.1-9
Hauptverfasser:	Munir, Maliha T., Ponce, Christopher, Powell, Catherine A., Tarafdar, Kaiser, Yanagita, Teruyoshi, Choudhury, Mahua, Gollahon, Lauren S., Rahman, Shaikh M.
Format:	Artikel
Sprache:	eng
Schlagworte:	27-Hydroxycholesterol Breast cancer Breast Neoplasms - physiopathology Cell proliferation Cholesterol Cholesterol - metabolism Cytochrome P450 DNA methylation Epigenesis, Genetic Epigenetics Estrogen receptor Estrogen receptors Estrogens Female Fluidity Humans Lipid metabolism Liver X receptors Membrane fluidity Metastases miRNA Prognosis Statins Tumorigenesis Women
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