Non-B DNA conformations, mutagenesis and disease

Recent discoveries have revealed that simple repeating DNA sequences, which are known to adopt non-B DNA conformations (such as triplexes, cruciforms, slipped structures, left-handed Z-DNA and tetraplexes), are mutagenic. The mutagenesis is due to the non-B DNA conformation rather than to the DNA se...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2007-06, Vol.32 (6), p.271-278
1. Verfasser:	Wells, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA - chemistry DNA - genetics DNA, Bacterial - chemistry DNA, Superhelical - chemistry Genetic Diseases, Inborn - genetics Humans Mutagenesis - genetics Nucleic Acid Conformation Plasmids - genetics
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