Peroxiredoxin2 Deficiency Aggravates Aging-Induced Insulin Resistance and Declines Muscle Strength

Abstract This study examined the role of peroxiredoxin2 (Prx2) in aging-induced insulin resistance and reduction in skeletal muscle function in young (2-month-old) and old (24-month-old) Prx2 knockout (KO) and wild-type mice. Plasma insulin levels increased with aging in Prx2 KO mice but not in wild...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2019-01, Vol.74 (2), p.147-154
Hauptverfasser:	Cha, Hye-Na, Park, Soyoung, Dan, Yongwook, Kim, Jae-Ryong, Park, So-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Genotypes Insulin Insulin resistance Intracellular signalling Muscle strength Muscular system Oxidative stress p53 Protein Skeletal muscle Young adults
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