On the needle clogging of staked-in-needle pre-filled syringes: Mechanism of liquid entering the needle and solidification process

[Display omitted] Staked-in-needle prefilled syringes (SIN-PFS) are widely used for the parenteral administration of drug product solutions. During stability studies, clogging of the injection needle was observed in syringes filled with concentrated antibody solution. A prerequisite for this phenome...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2018-07, Vol.128, p.272-281
Hauptverfasser:	De Bardi, M., Müller, R., Grünzweig, C., Mannes, D., Boillat, P., Rigollet, M., Bamberg, F., Jung, T.A., Yang, K.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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