A real time screening assay for cannabinoid CB1 receptor-mediated signaling

The cannabinoid CB1 receptor is expressed throughout the central nervous system where it functions to regulate neurotransmitter release and synaptic plasticity. While the CB1 receptor has been identified as a target for both natural and synthetic cannabinoids, the specific downstream signaling pathw...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2018-11, Vol.94 (Pt 1), p.44-49
Hauptverfasser:	Andersen, Haley K., Piroli, Gerardo G., Walsh, Kenneth B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoxazines - pharmacology Biological Assay - methods Cannabinoids - metabolism Cell Line, Tumor Fluorescence Fluorescent Dyes - metabolism GTP-Binding Proteins - metabolism Membrane Potentials - drug effects Mice Morpholines - pharmacology Naphthalenes - pharmacology Receptor, Cannabinoid, CB1 - metabolism Rimonabant - pharmacology Signal Transduction - drug effects
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