Salt formation improved the properties of a candidate drug during early formulation development

The purpose of this study was to investigate if AZD5329, a dual neurokinin NK1/2 receptor antagonist, is a suitable candidate for further development as an oral immediate release (IR) solid dosage form as a final product. The neutral form of AZD5329 has only been isolated as amorphous material. In o...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2018-07, Vol.120, p.162-171
Hauptverfasser:	Sigfridsson, Kalle, Ahlqvist, Matti, Lindsjö, Martin, Paulsson, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Calorimetry, Differential Scanning Crystallization Crystallography, X-Ray Dosage Forms Drug Compounding Drug Liberation Drug Stability Drug Storage Fumarates - administration & dosage Fumarates - chemistry Fumarates - pharmacology Humidity Hydrogen-Ion Concentration IBS Maleates - administration & dosage Maleates - chemistry Maleates - pharmacology Neurokinin-1 Receptor Antagonists - administration & dosage Neurokinin-1 Receptor Antagonists - chemistry Neurokinin-1 Receptor Antagonists - pharmacology NK receptor Powder Diffraction Preformulation Receptors, Neurokinin-2 - antagonists & inhibitors Receptors, Neurokinin-2 - metabolism Salt screen Solid-state Solubility Stability Technology, Pharmaceutical - methods Temperature Thermogravimetry Time Factors Wettability
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