Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient MRL/lpr Mice

Systemic lupus erythematosus (SLE) is an autoimmune disease posing threats to multiple organs in the human body. As a typical manifestation of SLE, lupus nephritis is characterized by a series of pathological changes in glomerulus as well as accumulation of pathogenic autoreactive IgG with complemen...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-06, Vol.200 (12), p.3905-3912
Hauptverfasser:	Hao, Fengqi, Tian, Miaomiao, Feng, Yunpeng, Quan, Chao, Chen, Yixi, Chen, Shuai, Wei, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Class switching Complement activation Creatinine Glomerulus Immunoglobulin G Inflammation Kidneys Life span Lupus Lupus nephritis Mice Nephritis Organs Proteinuria Recombination Somatic hypermutation Systemic lupus erythematosus Urea
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