The Peripheral Versus Central Antinociception of a Novel Opioid Agonist: Acute Inflammatory Pain in Rats

Opioid analgesics devoid of central side effects are unmet medical need in the treatment of acute pain (e.g. post-operative pain). Recently, we have reported on 14- O -methylmorphine-6- O -sulfate (14- O -MeM6SU), a novel opioid agonist of high efficacy producing peripheral antinociception in subchr...

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Veröffentlicht in:	Neurochemical research 2018-06, Vol.43 (6), p.1250-1257
Hauptverfasser:	Balogh, Mihály, Zádori, Zoltán S., Lázár, Bernadette, Karádi, Dávid, László, Szilvia, Mousa, Shaaban A., Hosztafi, Sándor, Zádor, Ferenc, Riba, Pál, Schäfer, Michael, Fürst, Susanna, Al-Khrasani, Mahmoud
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Pain - drug therapy Acute Pain - metabolism Acute Pain - psychology Analgesics Analgesics - administration & dosage Analgesics - chemistry Analgesics, Opioid - administration & dosage Analgesics, Opioid - chemistry Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Codeine - administration & dosage Codeine - analogs & derivatives Codeine - chemistry Dose-Response Relationship, Drug Formaldehyde Inflammation Inflammation - drug therapy Inflammation - metabolism Injections, Subcutaneous Isoflurane Male Morphine Naloxone Narcotics Neurochemistry Neurology Neurosciences Opioids Original Paper Pain Pain Measurement - drug effects Pain Measurement - methods Pain perception Phases Rats Rats, Wistar Righting reflex Side effects Sulfate
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