Beta and Gamma Oscillations in Prefrontal Cortex During NMDA Hypofunction: An In Vitro Model of Schizophrenia Features

•NMDAr blockers induce schizophrenia-like behavioral and electrophysiological features.•We blocked NMDAr with MK-801 and studied spontaneous activity in prefrontal slices.•MK-801 reduced slow oscillations and increased beta-gamma rhythms during Up states.•Clozapine prevented the increase in beta-gam...

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Veröffentlicht in:	Neuroscience 2018-07, Vol.383, p.138-149
Hauptverfasser:	Rebollo, Beatriz, Perez-Zabalza, Maria, Ruiz-Mejias, Marcel, Perez-Mendez, Lorena, Sanchez-Vives, Maria V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta frequency Beta Rhythm - drug effects Beta Rhythm - physiology Clozapine - pharmacology Disease Models, Animal Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Ferrets gamma frequency Gamma Rhythm - drug effects Gamma Rhythm - physiology In Vitro Techniques Male NMDAr hypofunction Organ Culture Techniques Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Schizophrenia slow oscillations Up states
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