The rare coexistence of high titer inhibitor development and gastrointestinal stromal tumor in a patient with severe hemophilia: A case report
Hemophilia is a hereditary disease with impaired blood coagulation due to a genetic deficiency of blood coagulation factors. The development of inhibitors further complicates the course of the disease and management. The case is here reported of a haemophilia patient who presented with coexisting de...
Gespeichert in:
| Veröffentlicht in: | Transfusion and apheresis science 2018-06, Vol.57 (3), p.398-400 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 400 |
|---|---|
| container_issue | 3 |
| container_start_page | 398 |
| container_title | Transfusion and apheresis science |
| container_volume | 57 |
| creator | Yıldız, Abdulkerim Şahin, Osman Yayar, Okan Öztürk, Çiğdem Pala Afacan Öztürk, Hacer Berna Maral, Senem Okutan, Harika Albayrak, Murat |
| description | Hemophilia is a hereditary disease with impaired blood coagulation due to a genetic deficiency of blood coagulation factors. The development of inhibitors further complicates the course of the disease and management. The case is here reported of a haemophilia patient who presented with coexisting development of high titer inhibitor with Gastrointestinal Stromal Tumor (GIST) diagnosis and was admitted with upper gastrointestinal system bleeding. The patient had no prior history of inhibitor presence. During all procedures including surgery, excellent hemostasis was achieved with rFVIIa treatment and no hemorrhagic complication was observed. To the best of our knowledge, this constitutes the first reported case of GIST associated with inhibitor development in a hemophilia A patient. |
| doi_str_mv | 10.1016/j.transci.2018.04.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2035241913</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1473050218300120</els_id><sourcerecordid>2035241913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-9432ba53480ccdd0d465114f1ded01afd14e924f8e8a4a7e5d696abfb5fb94183</originalsourceid><addsrcrecordid>eNqFkLlu3DAQhlnEiI_kERKwdLMKSVFayY1hGDkMGEjj1MSIHFmzkESF5NrOS-SZQ2HXblMNBviPmY-xT1IUUsj6y65IAeZoqVBCNoXQhVDlO3Ym9bbciEqoU3Ye404IuZVt_Z6dqnardK2aM_b3YUAeICC3Hl8oJpwtct_zgR4Hnihh4DQP1FHygTt8wtEvE86Jw-z4I8QUPM0JY6IZRr6uU55pP_nVyIEvkGjVP1MaeMwBuWvAyS8DjQRX_IZbiPkGXHxIH9hJD2PEj8d5wX59-_pw-2Nz__P73e3N_caWdZU2rS5VB1WpG2Gtc8LpupJS99KhExJ6JzW2SvcNNqBhi5Wr2xq6vqv6rtWyKS_Y5SF3Cf73Pl9vJooWxxFm9PtolCgrpWUryyytDlIbfIwBe7MEmiD8MVKYFb_ZmSN-s-I3QpuMP_s-Hyv23YTuzfXKPguuDwLMjz4RBpMjVvyOAtpknKf_VPwD-COe9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2035241913</pqid></control><display><type>article</type><title>The rare coexistence of high titer inhibitor development and gastrointestinal stromal tumor in a patient with severe hemophilia: A case report</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Yıldız, Abdulkerim ; Şahin, Osman ; Yayar, Okan ; Öztürk, Çiğdem Pala ; Afacan Öztürk, Hacer Berna ; Maral, Senem ; Okutan, Harika ; Albayrak, Murat</creator><creatorcontrib>Yıldız, Abdulkerim ; Şahin, Osman ; Yayar, Okan ; Öztürk, Çiğdem Pala ; Afacan Öztürk, Hacer Berna ; Maral, Senem ; Okutan, Harika ; Albayrak, Murat</creatorcontrib><description>Hemophilia is a hereditary disease with impaired blood coagulation due to a genetic deficiency of blood coagulation factors. The development of inhibitors further complicates the course of the disease and management. The case is here reported of a haemophilia patient who presented with coexisting development of high titer inhibitor with Gastrointestinal Stromal Tumor (GIST) diagnosis and was admitted with upper gastrointestinal system bleeding. The patient had no prior history of inhibitor presence. During all procedures including surgery, excellent hemostasis was achieved with rFVIIa treatment and no hemorrhagic complication was observed. To the best of our knowledge, this constitutes the first reported case of GIST associated with inhibitor development in a hemophilia A patient.</description><identifier>ISSN: 1473-0502</identifier><identifier>DOI: 10.1016/j.transci.2018.04.023</identifier><identifier>PMID: 29724628</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Gastrointestinal stromal tumor ; Health technology assessment ; Hemophilia ; Inhibitor</subject><ispartof>Transfusion and apheresis science, 2018-06, Vol.57 (3), p.398-400</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-9432ba53480ccdd0d465114f1ded01afd14e924f8e8a4a7e5d696abfb5fb94183</citedby><cites>FETCH-LOGICAL-c365t-9432ba53480ccdd0d465114f1ded01afd14e924f8e8a4a7e5d696abfb5fb94183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1473050218300120$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29724628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yıldız, Abdulkerim</creatorcontrib><creatorcontrib>Şahin, Osman</creatorcontrib><creatorcontrib>Yayar, Okan</creatorcontrib><creatorcontrib>Öztürk, Çiğdem Pala</creatorcontrib><creatorcontrib>Afacan Öztürk, Hacer Berna</creatorcontrib><creatorcontrib>Maral, Senem</creatorcontrib><creatorcontrib>Okutan, Harika</creatorcontrib><creatorcontrib>Albayrak, Murat</creatorcontrib><title>The rare coexistence of high titer inhibitor development and gastrointestinal stromal tumor in a patient with severe hemophilia: A case report</title><title>Transfusion and apheresis science</title><addtitle>Transfus Apher Sci</addtitle><description>Hemophilia is a hereditary disease with impaired blood coagulation due to a genetic deficiency of blood coagulation factors. The development of inhibitors further complicates the course of the disease and management. The case is here reported of a haemophilia patient who presented with coexisting development of high titer inhibitor with Gastrointestinal Stromal Tumor (GIST) diagnosis and was admitted with upper gastrointestinal system bleeding. The patient had no prior history of inhibitor presence. During all procedures including surgery, excellent hemostasis was achieved with rFVIIa treatment and no hemorrhagic complication was observed. To the best of our knowledge, this constitutes the first reported case of GIST associated with inhibitor development in a hemophilia A patient.</description><subject>Gastrointestinal stromal tumor</subject><subject>Health technology assessment</subject><subject>Hemophilia</subject><subject>Inhibitor</subject><issn>1473-0502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkLlu3DAQhlnEiI_kERKwdLMKSVFayY1hGDkMGEjj1MSIHFmzkESF5NrOS-SZQ2HXblMNBviPmY-xT1IUUsj6y65IAeZoqVBCNoXQhVDlO3Ym9bbciEqoU3Ye404IuZVt_Z6dqnardK2aM_b3YUAeICC3Hl8oJpwtct_zgR4Hnihh4DQP1FHygTt8wtEvE86Jw-z4I8QUPM0JY6IZRr6uU55pP_nVyIEvkGjVP1MaeMwBuWvAyS8DjQRX_IZbiPkGXHxIH9hJD2PEj8d5wX59-_pw-2Nz__P73e3N_caWdZU2rS5VB1WpG2Gtc8LpupJS99KhExJ6JzW2SvcNNqBhi5Wr2xq6vqv6rtWyKS_Y5SF3Cf73Pl9vJooWxxFm9PtolCgrpWUryyytDlIbfIwBe7MEmiD8MVKYFb_ZmSN-s-I3QpuMP_s-Hyv23YTuzfXKPguuDwLMjz4RBpMjVvyOAtpknKf_VPwD-COe9w</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Yıldız, Abdulkerim</creator><creator>Şahin, Osman</creator><creator>Yayar, Okan</creator><creator>Öztürk, Çiğdem Pala</creator><creator>Afacan Öztürk, Hacer Berna</creator><creator>Maral, Senem</creator><creator>Okutan, Harika</creator><creator>Albayrak, Murat</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>The rare coexistence of high titer inhibitor development and gastrointestinal stromal tumor in a patient with severe hemophilia: A case report</title><author>Yıldız, Abdulkerim ; Şahin, Osman ; Yayar, Okan ; Öztürk, Çiğdem Pala ; Afacan Öztürk, Hacer Berna ; Maral, Senem ; Okutan, Harika ; Albayrak, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-9432ba53480ccdd0d465114f1ded01afd14e924f8e8a4a7e5d696abfb5fb94183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Gastrointestinal stromal tumor</topic><topic>Health technology assessment</topic><topic>Hemophilia</topic><topic>Inhibitor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yıldız, Abdulkerim</creatorcontrib><creatorcontrib>Şahin, Osman</creatorcontrib><creatorcontrib>Yayar, Okan</creatorcontrib><creatorcontrib>Öztürk, Çiğdem Pala</creatorcontrib><creatorcontrib>Afacan Öztürk, Hacer Berna</creatorcontrib><creatorcontrib>Maral, Senem</creatorcontrib><creatorcontrib>Okutan, Harika</creatorcontrib><creatorcontrib>Albayrak, Murat</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion and apheresis science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yıldız, Abdulkerim</au><au>Şahin, Osman</au><au>Yayar, Okan</au><au>Öztürk, Çiğdem Pala</au><au>Afacan Öztürk, Hacer Berna</au><au>Maral, Senem</au><au>Okutan, Harika</au><au>Albayrak, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rare coexistence of high titer inhibitor development and gastrointestinal stromal tumor in a patient with severe hemophilia: A case report</atitle><jtitle>Transfusion and apheresis science</jtitle><addtitle>Transfus Apher Sci</addtitle><date>2018-06</date><risdate>2018</risdate><volume>57</volume><issue>3</issue><spage>398</spage><epage>400</epage><pages>398-400</pages><issn>1473-0502</issn><abstract>Hemophilia is a hereditary disease with impaired blood coagulation due to a genetic deficiency of blood coagulation factors. The development of inhibitors further complicates the course of the disease and management. The case is here reported of a haemophilia patient who presented with coexisting development of high titer inhibitor with Gastrointestinal Stromal Tumor (GIST) diagnosis and was admitted with upper gastrointestinal system bleeding. The patient had no prior history of inhibitor presence. During all procedures including surgery, excellent hemostasis was achieved with rFVIIa treatment and no hemorrhagic complication was observed. To the best of our knowledge, this constitutes the first reported case of GIST associated with inhibitor development in a hemophilia A patient.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29724628</pmid><doi>10.1016/j.transci.2018.04.023</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1473-0502 |
| ispartof | Transfusion and apheresis science, 2018-06, Vol.57 (3), p.398-400 |
| issn | 1473-0502 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2035241913 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Gastrointestinal stromal tumor Health technology assessment Hemophilia Inhibitor |
| title | The rare coexistence of high titer inhibitor development and gastrointestinal stromal tumor in a patient with severe hemophilia: A case report |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A54%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20rare%20coexistence%20of%20high%20titer%20inhibitor%20development%20and%20gastrointestinal%20stromal%20tumor%20in%20a%20patient%20with%20severe%20hemophilia:%20A%20case%20report&rft.jtitle=Transfusion%20and%20apheresis%20science&rft.au=Y%C4%B1ld%C4%B1z,%20Abdulkerim&rft.date=2018-06&rft.volume=57&rft.issue=3&rft.spage=398&rft.epage=400&rft.pages=398-400&rft.issn=1473-0502&rft_id=info:doi/10.1016/j.transci.2018.04.023&rft_dat=%3Cproquest_cross%3E2035241913%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2035241913&rft_id=info:pmid/29724628&rft_els_id=S1473050218300120&rfr_iscdi=true |