Synthesis of 17β-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells

The synthesis of two new highly potent 17β-estradiol-linked platinum(II) complexes is described. The new molecules are linked at position 16 of the steroid nucleus with an alkyl chain. They are made from estrone in nine chemical steps with an overall yield exceeding 10%. The biological activity of t...

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Veröffentlicht in:	Bioorganic chemistry 2005-02, Vol.33 (1), p.1-15
Hauptverfasser:	Perron, Valérie, Rabouin, Daniel, Asselin, Éric, Parent, Sophie, C.-Gaudreault, René, Bérubé, Gervais
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor agents Breast cancer Estradiol Hybrid estradiol-Pt(II) complexes Platinum(II) complexes
Online-Zugang:	Volltext
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