Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins

Ribosome-inactivating proteins (RIPs) display adenine polynucleotide glycosylase activity on different nucleic acid substrates, which at the ribosomal level is responsible for the arrest of protein synthesis. Some type 2 RIPs, namely ricin and related proteins, are extremely toxic to mammalian cells...

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Veröffentlicht in:	FEBS letters 2004-04, Vol.563 (1), p.219-222
Hauptverfasser:	Barbieri, Luigi, Ciani, Marialibera, Girbés, Tomás, Liu, Wang-yi, Van Damme, Els J.M, Peumans, Willy J, Stirpe, Fiorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abrin - toxicity Adenine polynucleotide glycosylase Algal Proteins Animals Enzymes - metabolism Glycoproteins - toxicity hsDNA, herring sperm DNA Lectin Microsomes, Liver - chemistry N-Glycosyl Hydrolases - metabolism Plant Lectins - metabolism Plant Lectins - toxicity Plant Preparations - toxicity Plant Proteins - metabolism Protein synthesis Proteins - metabolism Rats Ribosomal Proteins - metabolism Ribosome Inactivating Proteins Ribosome Inactivating Proteins, Type 2 Ribosome-inactivating protein Ribosomes - metabolism Ricin - toxicity RIP, ribosome-inactivating protein Substrate Specificity Toxins, Biological - toxicity
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