Skeletal Muscle Susceptibility to Clofibrate Induction of Lesions in Rats

Morphological changes induced by clofibrate in type-1 predominant soleus, type-2 predominant tensor fasciae latae, and type-1 and -2 mixed biceps femoris muscles and diaphragm in rats were investigated. Administration of the agent at 500 or 750 mg/kg/day by oral gavage for 14 or 28 days caused lesio...

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Veröffentlicht in:	Toxicologic pathology 2007-06, Vol.35 (4), p.517-520
Hauptverfasser:	Okada, Miyoko, Inoue, Yoshimi, Ube, Masayuki, Sano, Fumiko, Ikeda, Itsuko, Sugimoto, Jiro, Takagi, Shiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Clofibrate - toxicity Diaphragm - pathology Female Hypolipidemic Agents - toxicity Medical sciences Microscopy, Electron Mitochondria, Muscle - drug effects Mitochondria, Muscle - pathology Mitochondria, Muscle - ultrastructure Muscle, Skeletal - pathology Muscle, Skeletal - ultrastructure Muscular Diseases - chemically induced Muscular Diseases - pathology Rats Rats, Sprague-Dawley Toxicology
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