Skeletal Muscle Susceptibility to Clofibrate Induction of Lesions in Rats
Morphological changes induced by clofibrate in type-1 predominant soleus, type-2 predominant tensor fasciae latae, and type-1 and -2 mixed biceps femoris muscles and diaphragm in rats were investigated. Administration of the agent at 500 or 750 mg/kg/day by oral gavage for 14 or 28 days caused lesio...
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| Veröffentlicht in: | Toxicologic pathology 2007-06, Vol.35 (4), p.517-520 |
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| creator | Okada, Miyoko Inoue, Yoshimi Ube, Masayuki Sano, Fumiko Ikeda, Itsuko Sugimoto, Jiro Takagi, Shiro |
| description | Morphological changes induced by clofibrate in type-1 predominant soleus, type-2 predominant tensor fasciae latae, and type-1 and -2 mixed biceps femoris muscles and diaphragm in rats were investigated. Administration of the agent at 500 or 750 mg/kg/day by oral gavage for 14 or 28 days caused lesions in the soleus muscle and diaphragm, bur no changes in the tensor fasciae latae and biceps femoris muscles. In soleus muscle, vacuolation of muscle fibers was observed in all animals treated with clofibrate, and degeneration of muscle fibers and infiltration of leukocytes were noted at 750 mg/kg/day. In diaphragm, vacuolation of muscle fibers was also observed in all animals treated with clofibrate, and these lesions were located in type-1 skeletal muscles densely stained with NADH-TR. The vacuoles seen in soleus muscle and diaphragm were positive for oil red O staining. In addition, increase of lipid droplets and mitochondrial hypertrophy was seen in soleus muscle, ultrastructurally. These data suggest that sensitivity to clofibrate-induced muscle toxicity differs among muscles, with type-1 fibers being susceptible. |
| doi_str_mv | 10.1080/01926230701338925 |
| format | Article |
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Administration of the agent at 500 or 750 mg/kg/day by oral gavage for 14 or 28 days caused lesions in the soleus muscle and diaphragm, bur no changes in the tensor fasciae latae and biceps femoris muscles. In soleus muscle, vacuolation of muscle fibers was observed in all animals treated with clofibrate, and degeneration of muscle fibers and infiltration of leukocytes were noted at 750 mg/kg/day. In diaphragm, vacuolation of muscle fibers was also observed in all animals treated with clofibrate, and these lesions were located in type-1 skeletal muscles densely stained with NADH-TR. The vacuoles seen in soleus muscle and diaphragm were positive for oil red O staining. In addition, increase of lipid droplets and mitochondrial hypertrophy was seen in soleus muscle, ultrastructurally. These data suggest that sensitivity to clofibrate-induced muscle toxicity differs among muscles, with type-1 fibers being susceptible.</description><identifier>ISSN: 0192-6233</identifier><identifier>EISSN: 1533-1601</identifier><identifier>DOI: 10.1080/01926230701338925</identifier><identifier>PMID: 17562484</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Clofibrate - toxicity ; Diaphragm - pathology ; Female ; Hypolipidemic Agents - toxicity ; Medical sciences ; Microscopy, Electron ; Mitochondria, Muscle - drug effects ; Mitochondria, Muscle - pathology ; Mitochondria, Muscle - ultrastructure ; Muscle, Skeletal - pathology ; Muscle, Skeletal - ultrastructure ; Muscular Diseases - chemically induced ; Muscular Diseases - pathology ; Rats ; Rats, Sprague-Dawley ; Toxicology</subject><ispartof>Toxicologic pathology, 2007-06, Vol.35 (4), p.517-520</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-4c3dbb0241fc3898fb51345bc5461e00d576efe1ff5358a25b90c6596b4eb5ad3</citedby><cites>FETCH-LOGICAL-c465t-4c3dbb0241fc3898fb51345bc5461e00d576efe1ff5358a25b90c6596b4eb5ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1080/01926230701338925$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1080/01926230701338925$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20664238$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17562484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okada, Miyoko</creatorcontrib><creatorcontrib>Inoue, Yoshimi</creatorcontrib><creatorcontrib>Ube, Masayuki</creatorcontrib><creatorcontrib>Sano, Fumiko</creatorcontrib><creatorcontrib>Ikeda, Itsuko</creatorcontrib><creatorcontrib>Sugimoto, Jiro</creatorcontrib><creatorcontrib>Takagi, Shiro</creatorcontrib><title>Skeletal Muscle Susceptibility to Clofibrate Induction of Lesions in Rats</title><title>Toxicologic pathology</title><addtitle>Toxicol Pathol</addtitle><description>Morphological changes induced by clofibrate in type-1 predominant soleus, type-2 predominant tensor fasciae latae, and type-1 and -2 mixed biceps femoris muscles and diaphragm in rats were investigated. Administration of the agent at 500 or 750 mg/kg/day by oral gavage for 14 or 28 days caused lesions in the soleus muscle and diaphragm, bur no changes in the tensor fasciae latae and biceps femoris muscles. In soleus muscle, vacuolation of muscle fibers was observed in all animals treated with clofibrate, and degeneration of muscle fibers and infiltration of leukocytes were noted at 750 mg/kg/day. In diaphragm, vacuolation of muscle fibers was also observed in all animals treated with clofibrate, and these lesions were located in type-1 skeletal muscles densely stained with NADH-TR. The vacuoles seen in soleus muscle and diaphragm were positive for oil red O staining. In addition, increase of lipid droplets and mitochondrial hypertrophy was seen in soleus muscle, ultrastructurally. These data suggest that sensitivity to clofibrate-induced muscle toxicity differs among muscles, with type-1 fibers being susceptible.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Clofibrate - toxicity</subject><subject>Diaphragm - pathology</subject><subject>Female</subject><subject>Hypolipidemic Agents - toxicity</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Mitochondria, Muscle - drug effects</subject><subject>Mitochondria, Muscle - pathology</subject><subject>Mitochondria, Muscle - ultrastructure</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - ultrastructure</subject><subject>Muscular Diseases - chemically induced</subject><subject>Muscular Diseases - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Toxicology</subject><issn>0192-6233</issn><issn>1533-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMoWh8_wI1ko7upN89mllJ8FCqCj_WQZBKJpjN1kln474206EJwdS_c75x7OAidEpgSUHAJpKaSMpgBYUzVVOygCRGMVUQC2UWT73tVAHaADlN6AyCKcNhHB2QmJOWKT9Di6d1Fl3XE92Oy0eGnMtw6BxNiyJ8493geex_MoLPDi64dbQ59h3uPly6VLeHQ4Ued0zHa8zomd7KdR-jl5vp5flctH24X86tlZbkUueKWtcYA5cTbkll5IwjjwljBJXEArZhJ5x3xXjChNBWmBitFLQ13RuiWHaGLje966D9Gl3KzCiVyjLpz_ZgaCowrVcsCkg1ohz6lwflmPYSVHj4bAs13f82f_ormbGs-mpVrfxXbwgpwvgV0sjr6QXc2pB-OgpScMlW46YZL-tU1b_04dKWUfz5_ATwFhCg</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Okada, Miyoko</creator><creator>Inoue, Yoshimi</creator><creator>Ube, Masayuki</creator><creator>Sano, Fumiko</creator><creator>Ikeda, Itsuko</creator><creator>Sugimoto, Jiro</creator><creator>Takagi, Shiro</creator><general>SAGE Publications</general><general>Sage</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200706</creationdate><title>Skeletal Muscle Susceptibility to Clofibrate Induction of Lesions in Rats</title><author>Okada, Miyoko ; Inoue, Yoshimi ; Ube, Masayuki ; Sano, Fumiko ; Ikeda, Itsuko ; Sugimoto, Jiro ; Takagi, Shiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-4c3dbb0241fc3898fb51345bc5461e00d576efe1ff5358a25b90c6596b4eb5ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Clofibrate - toxicity</topic><topic>Diaphragm - pathology</topic><topic>Female</topic><topic>Hypolipidemic Agents - toxicity</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Mitochondria, Muscle - drug effects</topic><topic>Mitochondria, Muscle - pathology</topic><topic>Mitochondria, Muscle - ultrastructure</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - ultrastructure</topic><topic>Muscular Diseases - chemically induced</topic><topic>Muscular Diseases - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okada, Miyoko</creatorcontrib><creatorcontrib>Inoue, Yoshimi</creatorcontrib><creatorcontrib>Ube, Masayuki</creatorcontrib><creatorcontrib>Sano, Fumiko</creatorcontrib><creatorcontrib>Ikeda, Itsuko</creatorcontrib><creatorcontrib>Sugimoto, Jiro</creatorcontrib><creatorcontrib>Takagi, Shiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicologic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okada, Miyoko</au><au>Inoue, Yoshimi</au><au>Ube, Masayuki</au><au>Sano, Fumiko</au><au>Ikeda, Itsuko</au><au>Sugimoto, Jiro</au><au>Takagi, Shiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal Muscle Susceptibility to Clofibrate Induction of Lesions in Rats</atitle><jtitle>Toxicologic pathology</jtitle><addtitle>Toxicol Pathol</addtitle><date>2007-06</date><risdate>2007</risdate><volume>35</volume><issue>4</issue><spage>517</spage><epage>520</epage><pages>517-520</pages><issn>0192-6233</issn><eissn>1533-1601</eissn><abstract>Morphological changes induced by clofibrate in type-1 predominant soleus, type-2 predominant tensor fasciae latae, and type-1 and -2 mixed biceps femoris muscles and diaphragm in rats were investigated. Administration of the agent at 500 or 750 mg/kg/day by oral gavage for 14 or 28 days caused lesions in the soleus muscle and diaphragm, bur no changes in the tensor fasciae latae and biceps femoris muscles. In soleus muscle, vacuolation of muscle fibers was observed in all animals treated with clofibrate, and degeneration of muscle fibers and infiltration of leukocytes were noted at 750 mg/kg/day. In diaphragm, vacuolation of muscle fibers was also observed in all animals treated with clofibrate, and these lesions were located in type-1 skeletal muscles densely stained with NADH-TR. The vacuoles seen in soleus muscle and diaphragm were positive for oil red O staining. In addition, increase of lipid droplets and mitochondrial hypertrophy was seen in soleus muscle, ultrastructurally. These data suggest that sensitivity to clofibrate-induced muscle toxicity differs among muscles, with type-1 fibers being susceptible.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>17562484</pmid><doi>10.1080/01926230701338925</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Clofibrate - toxicity Diaphragm - pathology Female Hypolipidemic Agents - toxicity Medical sciences Microscopy, Electron Mitochondria, Muscle - drug effects Mitochondria, Muscle - pathology Mitochondria, Muscle - ultrastructure Muscle, Skeletal - pathology Muscle, Skeletal - ultrastructure Muscular Diseases - chemically induced Muscular Diseases - pathology Rats Rats, Sprague-Dawley Toxicology |
| title | Skeletal Muscle Susceptibility to Clofibrate Induction of Lesions in Rats |
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