Ethanol exhibits specificity in its effects on differentiation of hematopoietic progenitors

Ethanol is a known teratogen but the mechanisms by which this simple compound affects fetal development remain unresolved. The goal of the current study was to determine the mechanism by which ethanol affects lymphoid differentiation using an in vitro model of ethanol exposure. Primitive hematopoiet...

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Veröffentlicht in:	Cellular immunology 2009, Vol.255 (1), p.1-7
Hauptverfasser:	Wang, Hao, Zhou, Huijuan, Chervenak, Robert, Moscatello, Kim M., Brunson, Lee Ellen, Chervenak, Deborah C., Wolcott, R. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B cells Bone Marrow Cells - drug effects Bone Marrow Cells - physiology Cell differentiation Cell Differentiation - drug effects Cell Differentiation - physiology Cell Proliferation Cells, Cultured Dose-Response Relationship, Drug Ethanol - pharmacology Female Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Humans Interleukin-7 - genetics Interleukin-7 - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Monocytes/macrophages PAX5 Transcription Factor - genetics PAX5 Transcription Factor - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - metabolism Rodent Trans-Activators - genetics Trans-Activators - metabolism
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