DNA sequence–selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145

AS-I-145 is a novel achiral seco -amino-cyclopropylbenz[ e ]indolone ( seco -amino-CBI) analogue of duocarmycin that has evolved from an alternative strategy of designing CC-1065/duocarmycin agents lacking the characteristic chiral center of the natural agents. The sequence specificity of this compo...

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Veröffentlicht in:Molecular cancer therapeutics 2007-10, Vol.6 (10), p.2708-2718
Hauptverfasser: Kiakos, Konstantinos, Sato, Atsushi, Asao, Tetsuji, McHugh, Peter J, Lee, Moses, Hartley, John A
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Sprache:eng
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