Critical Role of Helix 4 of HIV-1 Capsid C-terminal Domain in Interactions with Human Lysyl-tRNA Synthetase

Human tRNALys3 is used as the primer for human immunodeficiency virus type 1 (HIV-1) reverse transcription. HIV-1 Gag and GagPol, as well as host cell factor lysyl-tRNA synthetase (LysRS), are required for specific packaging of tRNALys into virions. Gag alone is sufficient for packaging of LysRS, an...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2007-11, Vol.282 (44), p.32274-32279
Hauptverfasser:	Kovaleski, Brandie J., Kennedy, Robert, Khorchid, Ahmad, Kleiman, Lawrence, Matsuo, Hiroshi, Musier-Forsyth, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence gag Gene Products, Human Immunodeficiency Virus - chemistry gag Gene Products, Human Immunodeficiency Virus - metabolism HIV-1 - metabolism Human immunodeficiency virus 1 Humans Lysine-tRNA Ligase - chemistry Lysine-tRNA Ligase - metabolism Models, Molecular Molecular Sequence Data Mutagenesis Protein Interaction Domains and Motifs Protein Interaction Mapping Protein Structure, Secondary
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!