DNA Polymerases eta and {theta} Function in the Same Genetic Pathway to Generate Mutations at A/T during Somatic Hypermutation of Ig Genes

Somatic hypermutation of the Ig genes requires the activity of multiple DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs. Mice deficient for DNA polymerase eta (POLH) exhibited an similar to 80% reduction of the mutations at A/T, whereas absence of polymerase {theta}...

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Veröffentlicht in:	The Journal of biological chemistry 2007-06, Vol.282 (24), p.17387-17394
Hauptverfasser:	Masuda, Keiji, Ouchida, Rika, Hikida, Masaki, Kurosaki, Tomohiro, Yokoi, Masayuki, Masutani, Chikahide, Seki, Mineaki, Wood, Richard D, Hanaoka, Fumio, O-Wang, Jiyang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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