Cytotoxic, genotoxic and oxidative stress induced by 1,4-naphthoquinone in B16F1 melanoma tumor cells

Quinones have diverse pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, antipyretic and anticancer activity. The cytotoxic potential of 1,4-naphthoquinone (NQ14) was studied against B16F1 melanoma cells grown in vitro. NQ14 treatment resulted in a concentr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology in vitro 2009-03, Vol.23 (2), p.242-250
Hauptverfasser:	Kumar, Mandala Rayabandla Sunil, Aithal, Kiran, Rao, Bhuvanagiri Nageshwar, Udupa, Nayanabhirama, Rao, Bola Sadashiva Satish
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Naphthoquinone Animals Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Cell Line, Tumor Cell Survival - drug effects Cytotoxicity Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Formazans - metabolism Glutathione Glutathione - metabolism L-Lactate Dehydrogenase - metabolism Melanoma Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice Micronuclei Micronucleus Tests Naphthoquinones - toxicity Necrosis Necrosis - chemically induced Oxidative Stress - drug effects Reactive Oxygen Species Tetrazolium Salts - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!