Risk Factors for Renal Cell Cancer: The Multiethnic Cohort
The association of body size, lifestyle, and medical conditions with renal cell cancer risk was examined among 161,126 Hawaii–Los Angeles Multiethnic Cohort participants (1993–2002). After 8.3 years of follow-up, 347 renal cell cancer cases (220 men, 127 women) were identified. Renal cell cancer ris...
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| Veröffentlicht in: | American journal of epidemiology 2007-10, Vol.166 (8), p.932-940 |
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| creator | Setiawan, Veronica Wendy Stram, Daniel O. Nomura, Abraham M. Y. Kolonel, Laurence N. Henderson, Brian E. |
| description | The association of body size, lifestyle, and medical conditions with renal cell cancer risk was examined among 161,126 Hawaii–Los Angeles Multiethnic Cohort participants (1993–2002). After 8.3 years of follow-up, 347 renal cell cancer cases (220 men, 127 women) were identified. Renal cell cancer risk increased with increasing body mass index in men (multivariate relative risk (RR) = 1.06 per unit of body mass index, p = 0.001) and women (RR = 1.07, p < 0.0001). The relative risks associated with being obese compared with being lean were 1.76 (95% confidence interval (CI): 1.20, 2.58) for men and 2.27 (95% CI: 1.37, 3.74) for women. Hypertension was associated with renal cell cancer (RRmen = 1.42, 95% CI: 1.07, 1.87; RRwomen = 1.58, 95% CI: 1.09, 2.28). Smoking was confirmed to be a risk factor for both sexes. Among women, diuretic use was associated with increased risk (RR = 1.63, 95% CI: 1.04, 2.57), whereas physical activity was associated with reduced risk (ptrend = 0.027). Alcohol consumption was inversely associated with risk for men (ptrend = 0.045). Compared with nondrinkers, men who drank ≥1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes. |
| doi_str_mv | 10.1093/aje/kwm170 |
| format | Article |
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Y. ; Kolonel, Laurence N. ; Henderson, Brian E.</creator><creatorcontrib>Setiawan, Veronica Wendy ; Stram, Daniel O. ; Nomura, Abraham M. Y. ; Kolonel, Laurence N. ; Henderson, Brian E.</creatorcontrib><description>The association of body size, lifestyle, and medical conditions with renal cell cancer risk was examined among 161,126 Hawaii–Los Angeles Multiethnic Cohort participants (1993–2002). After 8.3 years of follow-up, 347 renal cell cancer cases (220 men, 127 women) were identified. Renal cell cancer risk increased with increasing body mass index in men (multivariate relative risk (RR) = 1.06 per unit of body mass index, p = 0.001) and women (RR = 1.07, p < 0.0001). The relative risks associated with being obese compared with being lean were 1.76 (95% confidence interval (CI): 1.20, 2.58) for men and 2.27 (95% CI: 1.37, 3.74) for women. Hypertension was associated with renal cell cancer (RRmen = 1.42, 95% CI: 1.07, 1.87; RRwomen = 1.58, 95% CI: 1.09, 2.28). Smoking was confirmed to be a risk factor for both sexes. Among women, diuretic use was associated with increased risk (RR = 1.63, 95% CI: 1.04, 2.57), whereas physical activity was associated with reduced risk (ptrend = 0.027). Alcohol consumption was inversely associated with risk for men (ptrend = 0.045). Compared with nondrinkers, men who drank ≥1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwm170</identifier><identifier>PMID: 17656615</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Aged ; Alcohol Drinking - adverse effects ; Analysis. Health state ; Biological and medical sciences ; Body Mass Index ; body size ; Cancer ; carcinoma ; Carcinoma, Renal Cell - epidemiology ; Carcinoma, Renal Cell - ethnology ; Carcinoma, Renal Cell - etiology ; Cohort Studies ; diuretics ; Diuretics - adverse effects ; Epidemiology ; Ethnic Groups - statistics & numerical data ; Female ; Gender differences ; General aspects ; Hawaii - epidemiology ; Humans ; hypertension ; Hypertension - complications ; Incidence ; Kidney diseases ; Kidney Neoplasms - epidemiology ; Kidney Neoplasms - ethnology ; Kidney Neoplasms - etiology ; Kidneys ; Life Style ; Los Angeles - epidemiology ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Nephrology. Urinary tract diseases ; Obesity - complications ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Racial differences ; renal cell ; Risk Assessment ; Risk Factors ; Sex Distribution ; smoking ; Smoking - adverse effects ; Surveys and Questionnaires ; Tumors of the urinary system</subject><ispartof>American journal of epidemiology, 2007-10, Vol.166 (8), p.932-940</ispartof><rights>American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2007</rights><rights>2008 INIST-CNRS</rights><rights>American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-8b591ccc46681ebe7416e97f5361ca5b44df10299f3c34eac8d747c091f56a193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19167931$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17656615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Setiawan, Veronica Wendy</creatorcontrib><creatorcontrib>Stram, Daniel O.</creatorcontrib><creatorcontrib>Nomura, Abraham M. Y.</creatorcontrib><creatorcontrib>Kolonel, Laurence N.</creatorcontrib><creatorcontrib>Henderson, Brian E.</creatorcontrib><title>Risk Factors for Renal Cell Cancer: The Multiethnic Cohort</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>The association of body size, lifestyle, and medical conditions with renal cell cancer risk was examined among 161,126 Hawaii–Los Angeles Multiethnic Cohort participants (1993–2002). After 8.3 years of follow-up, 347 renal cell cancer cases (220 men, 127 women) were identified. Renal cell cancer risk increased with increasing body mass index in men (multivariate relative risk (RR) = 1.06 per unit of body mass index, p = 0.001) and women (RR = 1.07, p < 0.0001). The relative risks associated with being obese compared with being lean were 1.76 (95% confidence interval (CI): 1.20, 2.58) for men and 2.27 (95% CI: 1.37, 3.74) for women. Hypertension was associated with renal cell cancer (RRmen = 1.42, 95% CI: 1.07, 1.87; RRwomen = 1.58, 95% CI: 1.09, 2.28). Smoking was confirmed to be a risk factor for both sexes. Among women, diuretic use was associated with increased risk (RR = 1.63, 95% CI: 1.04, 2.57), whereas physical activity was associated with reduced risk (ptrend = 0.027). Alcohol consumption was inversely associated with risk for men (ptrend = 0.045). Compared with nondrinkers, men who drank ≥1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes.</description><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>body size</subject><subject>Cancer</subject><subject>carcinoma</subject><subject>Carcinoma, Renal Cell - epidemiology</subject><subject>Carcinoma, Renal Cell - ethnology</subject><subject>Carcinoma, Renal Cell - etiology</subject><subject>Cohort Studies</subject><subject>diuretics</subject><subject>Diuretics - adverse effects</subject><subject>Epidemiology</subject><subject>Ethnic Groups - statistics & numerical data</subject><subject>Female</subject><subject>Gender differences</subject><subject>General aspects</subject><subject>Hawaii - epidemiology</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - complications</subject><subject>Incidence</subject><subject>Kidney diseases</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidney Neoplasms - ethnology</subject><subject>Kidney Neoplasms - etiology</subject><subject>Kidneys</subject><subject>Life Style</subject><subject>Los Angeles - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Obesity - complications</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Racial differences</subject><subject>renal cell</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>smoking</subject><subject>Smoking - adverse effects</subject><subject>Surveys and Questionnaires</subject><subject>Tumors of the urinary system</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LwzAYwPEgis7pxQ8gRdCDUJeneVu86VAn-MZQEC8hzVLWrVtm0qJ-eyMrDjx4SS4_nif5I3QA-AywJD09tb3ZxxwE3kAdoIKnPGN8E3UwxlkqM57toN0QphgDSIa30Q4IzjgH1kHnozLMkmttaudDUjifjOxCV8nAVvHQC2P9efI8scl9U9WlrSeL0iQDN3G-3kNbha6C3W_vLnq5vnoeDNO7x5vbwcVdahglddrPmQRjDOW8Dza3ggK3UhSMcDCa5ZSOC8CZlAUxhFpt-mNBhcESCsY1SNJFJ6u5S-_eGxtqNS-Die_TC-uaoDJMKMUZj_DoD5y6xsffRENYHyjjLKLTFTLeheBtoZa-nGv_pQCrn5wq5lSrnBEfthObfG7Ha9r2i-C4BToYXRU-FivD2kngQhJYO9cs_1-YrlwZavv5K7WfKS6IYGr4-qZu6NPbZfaAFSHfAB-W5w</recordid><startdate>20071015</startdate><enddate>20071015</enddate><creator>Setiawan, Veronica Wendy</creator><creator>Stram, Daniel O.</creator><creator>Nomura, Abraham M. Y.</creator><creator>Kolonel, Laurence N.</creator><creator>Henderson, Brian E.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope></search><sort><creationdate>20071015</creationdate><title>Risk Factors for Renal Cell Cancer: The Multiethnic Cohort</title><author>Setiawan, Veronica Wendy ; Stram, Daniel O. ; Nomura, Abraham M. 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Health state</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>body size</topic><topic>Cancer</topic><topic>carcinoma</topic><topic>Carcinoma, Renal Cell - epidemiology</topic><topic>Carcinoma, Renal Cell - ethnology</topic><topic>Carcinoma, Renal Cell - etiology</topic><topic>Cohort Studies</topic><topic>diuretics</topic><topic>Diuretics - adverse effects</topic><topic>Epidemiology</topic><topic>Ethnic Groups - statistics & numerical data</topic><topic>Female</topic><topic>Gender differences</topic><topic>General aspects</topic><topic>Hawaii - epidemiology</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - complications</topic><topic>Incidence</topic><topic>Kidney diseases</topic><topic>Kidney Neoplasms - epidemiology</topic><topic>Kidney Neoplasms - ethnology</topic><topic>Kidney Neoplasms - etiology</topic><topic>Kidneys</topic><topic>Life Style</topic><topic>Los Angeles - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Obesity - complications</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Racial differences</topic><topic>renal cell</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>smoking</topic><topic>Smoking - adverse effects</topic><topic>Surveys and Questionnaires</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Setiawan, Veronica Wendy</creatorcontrib><creatorcontrib>Stram, Daniel O.</creatorcontrib><creatorcontrib>Nomura, Abraham M. 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Y.</au><au>Kolonel, Laurence N.</au><au>Henderson, Brian E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Renal Cell Cancer: The Multiethnic Cohort</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2007-10-15</date><risdate>2007</risdate><volume>166</volume><issue>8</issue><spage>932</spage><epage>940</epage><pages>932-940</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>The association of body size, lifestyle, and medical conditions with renal cell cancer risk was examined among 161,126 Hawaii–Los Angeles Multiethnic Cohort participants (1993–2002). After 8.3 years of follow-up, 347 renal cell cancer cases (220 men, 127 women) were identified. Renal cell cancer risk increased with increasing body mass index in men (multivariate relative risk (RR) = 1.06 per unit of body mass index, p = 0.001) and women (RR = 1.07, p < 0.0001). The relative risks associated with being obese compared with being lean were 1.76 (95% confidence interval (CI): 1.20, 2.58) for men and 2.27 (95% CI: 1.37, 3.74) for women. Hypertension was associated with renal cell cancer (RRmen = 1.42, 95% CI: 1.07, 1.87; RRwomen = 1.58, 95% CI: 1.09, 2.28). Smoking was confirmed to be a risk factor for both sexes. Among women, diuretic use was associated with increased risk (RR = 1.63, 95% CI: 1.04, 2.57), whereas physical activity was associated with reduced risk (ptrend = 0.027). Alcohol consumption was inversely associated with risk for men (ptrend = 0.045). Compared with nondrinkers, men who drank ≥1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>17656615</pmid><doi>10.1093/aje/kwm170</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alcohol Drinking - adverse effects Analysis. Health state Biological and medical sciences Body Mass Index body size Cancer carcinoma Carcinoma, Renal Cell - epidemiology Carcinoma, Renal Cell - ethnology Carcinoma, Renal Cell - etiology Cohort Studies diuretics Diuretics - adverse effects Epidemiology Ethnic Groups - statistics & numerical data Female Gender differences General aspects Hawaii - epidemiology Humans hypertension Hypertension - complications Incidence Kidney diseases Kidney Neoplasms - epidemiology Kidney Neoplasms - ethnology Kidney Neoplasms - etiology Kidneys Life Style Los Angeles - epidemiology Male Medical sciences Middle Aged Miscellaneous Nephrology. Urinary tract diseases Obesity - complications Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Racial differences renal cell Risk Assessment Risk Factors Sex Distribution smoking Smoking - adverse effects Surveys and Questionnaires Tumors of the urinary system |
| title | Risk Factors for Renal Cell Cancer: The Multiethnic Cohort |
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