Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma
This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection. The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens...
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| Veröffentlicht in: | Journal of laryngology and otology 2018-05, Vol.132 (5), p.446-451 |
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| container_title | Journal of laryngology and otology |
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| creator | Cakir Cetin, A Dogan, E Ozay, H Kumus, O Erdag, T K Karabay, N Sarioglu, S Ikiz, A O |
| description | This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection.
The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.
Submandibular gland involvement, via direct invasion from the anatomical proximity of T4a tumours, was evident in two patients. The floor of mouth location, either primarily or as an extension of the primary tumour, was the only risk factor for submandibular gland involvement in oral cavity carcinoma (p = 0.042). Tumour location, clinical and pathological tumour (T) and nodal (N) stages, and radiological suspicion of mandible invasion, were not found to be statistically relevant (p > 0.05).
The results suggest the feasibility of preserving the submandibular gland in early stage oral cavity carcinoma unless the tumour is located in, or extends to, the floor of mouth. |
| doi_str_mv | 10.1017/S0022215118000592 |
| format | Article |
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The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.
Submandibular gland involvement, via direct invasion from the anatomical proximity of T4a tumours, was evident in two patients. The floor of mouth location, either primarily or as an extension of the primary tumour, was the only risk factor for submandibular gland involvement in oral cavity carcinoma (p = 0.042). Tumour location, clinical and pathological tumour (T) and nodal (N) stages, and radiological suspicion of mandible invasion, were not found to be statistically relevant (p > 0.05).
The results suggest the feasibility of preserving the submandibular gland in early stage oral cavity carcinoma unless the tumour is located in, or extends to, the floor of mouth.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215118000592</identifier><identifier>PMID: 29720283</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cancer ; Carcinoma - pathology ; Carcinoma - surgery ; Dissection ; Exocrine glands ; Feasibility Studies ; Female ; Humans ; Lymphatic system ; Main Articles ; Male ; Mandible ; Metastasis ; Middle Aged ; Mouth ; Mouth - pathology ; Mouth - surgery ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Neck ; Neck Dissection - methods ; Neoplasm Invasiveness ; NMR ; Nuclear magnetic resonance ; Oral cancer ; Oral cavity ; Organ Sparing Treatments - methods ; Radiation therapy ; Retrospective Studies ; Risk Factors ; Squamous cell carcinoma ; Submandibular gland ; Submandibular Gland - pathology ; Submandibular Gland - surgery ; Surgery ; Treatment Outcome ; Tumors ; Young Adult</subject><ispartof>Journal of laryngology and otology, 2018-05, Vol.132 (5), p.446-451</ispartof><rights>Copyright © JLO (1984) Limited 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-ad17735eec7263803f3244d2956e9bae0040e22152c163656a37d637fc9002293</citedby><cites>FETCH-LOGICAL-c373t-ad17735eec7263803f3244d2956e9bae0040e22152c163656a37d637fc9002293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215118000592/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29720283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cakir Cetin, A</creatorcontrib><creatorcontrib>Dogan, E</creatorcontrib><creatorcontrib>Ozay, H</creatorcontrib><creatorcontrib>Kumus, O</creatorcontrib><creatorcontrib>Erdag, T K</creatorcontrib><creatorcontrib>Karabay, N</creatorcontrib><creatorcontrib>Sarioglu, S</creatorcontrib><creatorcontrib>Ikiz, A O</creatorcontrib><title>Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection.
The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.
Submandibular gland involvement, via direct invasion from the anatomical proximity of T4a tumours, was evident in two patients. The floor of mouth location, either primarily or as an extension of the primary tumour, was the only risk factor for submandibular gland involvement in oral cavity carcinoma (p = 0.042). Tumour location, clinical and pathological tumour (T) and nodal (N) stages, and radiological suspicion of mandible invasion, were not found to be statistically relevant (p > 0.05).
The results suggest the feasibility of preserving the submandibular gland in early stage oral cavity carcinoma unless the tumour is located in, or extends to, the floor of mouth.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Dissection</subject><subject>Exocrine glands</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Main Articles</subject><subject>Male</subject><subject>Mandible</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mouth</subject><subject>Mouth - pathology</subject><subject>Mouth - surgery</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neck</subject><subject>Neck Dissection - methods</subject><subject>Neoplasm Invasiveness</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oral cancer</subject><subject>Oral cavity</subject><subject>Organ Sparing Treatments - methods</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Squamous cell carcinoma</subject><subject>Submandibular gland</subject><subject>Submandibular Gland - pathology</subject><subject>Submandibular Gland - surgery</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1LxDAQhoMo7rr6A7xIwYuX6uSjTXsU8QsWPKyeS5qmS9Y2WZN2Yf-9CbsqKJ4yYZ55Z-YdhM4xXGPA_GYBQAjBGcYFAGQlOUBTzFmRZiyHQzSN6TTmJ-jE-1VgMAdyjCak5ARIQaeoXYx1L0yj67ETLll2IU602QivrUnip1UhrnWnh21i2x2R-rVw2iwTo-R70mjvlRxigTaJdaJLpNhEXgontbG9OEVHrei8Otu_M_T2cP9695TOXx6f727nqaScDqloMOc0U0pyktMCaEsJYw0ps1yVtVAADFTcmEic0zzLBeVNTnkry7hrSWfoaqe7dvZjVH6oeu2l6sLQyo6-IkAZKVnwK6CXv9CVHZ0J0wUqo4zh4GKg8I6SznrvVFutne6F21YYqniE6s8RQs3FXjl4q5rvii_XA0D3oqKvnW6W6qf3_7KfVbaPcQ</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Cakir Cetin, A</creator><creator>Dogan, E</creator><creator>Ozay, H</creator><creator>Kumus, O</creator><creator>Erdag, T K</creator><creator>Karabay, N</creator><creator>Sarioglu, S</creator><creator>Ikiz, A O</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma</title><author>Cakir Cetin, A ; Dogan, E ; Ozay, H ; Kumus, O ; Erdag, T K ; Karabay, N ; Sarioglu, S ; Ikiz, A O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-ad17735eec7263803f3244d2956e9bae0040e22152c163656a37d637fc9002293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Dissection</topic><topic>Exocrine glands</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic system</topic><topic>Main Articles</topic><topic>Male</topic><topic>Mandible</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mouth</topic><topic>Mouth - pathology</topic><topic>Mouth - surgery</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neck</topic><topic>Neck Dissection - methods</topic><topic>Neoplasm Invasiveness</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oral cancer</topic><topic>Oral cavity</topic><topic>Organ Sparing Treatments - methods</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Squamous cell carcinoma</topic><topic>Submandibular gland</topic><topic>Submandibular Gland - pathology</topic><topic>Submandibular Gland - surgery</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cakir Cetin, A</creatorcontrib><creatorcontrib>Dogan, E</creatorcontrib><creatorcontrib>Ozay, H</creatorcontrib><creatorcontrib>Kumus, O</creatorcontrib><creatorcontrib>Erdag, T K</creatorcontrib><creatorcontrib>Karabay, N</creatorcontrib><creatorcontrib>Sarioglu, S</creatorcontrib><creatorcontrib>Ikiz, A O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cakir Cetin, A</au><au>Dogan, E</au><au>Ozay, H</au><au>Kumus, O</au><au>Erdag, T K</au><au>Karabay, N</au><au>Sarioglu, S</au><au>Ikiz, A O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2018-05</date><risdate>2018</risdate><volume>132</volume><issue>5</issue><spage>446</spage><epage>451</epage><pages>446-451</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><abstract>This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection.
The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.
Submandibular gland involvement, via direct invasion from the anatomical proximity of T4a tumours, was evident in two patients. The floor of mouth location, either primarily or as an extension of the primary tumour, was the only risk factor for submandibular gland involvement in oral cavity carcinoma (p = 0.042). Tumour location, clinical and pathological tumour (T) and nodal (N) stages, and radiological suspicion of mandible invasion, were not found to be statistically relevant (p > 0.05).
The results suggest the feasibility of preserving the submandibular gland in early stage oral cavity carcinoma unless the tumour is located in, or extends to, the floor of mouth.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>29720283</pmid><doi>10.1017/S0022215118000592</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of laryngology and otology, 2018-05, Vol.132 (5), p.446-451 |
| issn | 0022-2151 1748-5460 |
| language | eng |
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| source | MEDLINE; Cambridge Journals |
| subjects | Adult Aged Aged, 80 and over Cancer Carcinoma - pathology Carcinoma - surgery Dissection Exocrine glands Feasibility Studies Female Humans Lymphatic system Main Articles Male Mandible Metastasis Middle Aged Mouth Mouth - pathology Mouth - surgery Mouth Neoplasms - pathology Mouth Neoplasms - surgery Neck Neck Dissection - methods Neoplasm Invasiveness NMR Nuclear magnetic resonance Oral cancer Oral cavity Organ Sparing Treatments - methods Radiation therapy Retrospective Studies Risk Factors Squamous cell carcinoma Submandibular gland Submandibular Gland - pathology Submandibular Gland - surgery Surgery Treatment Outcome Tumors Young Adult |
| title | Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma |
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