Advances in the design of nanomaterial-based electrochemical affinity and enzymatic biosensors for metabolic biomarkers: A review
This review (with 340 refs) focuses on methods for specific and sensitive detection of metabolites for diagnostic purposes, with particular emphasis on electrochemical nanomaterial-based sensors. It also covers novel candidate metabolites as potential biomarkers for diseases such as neurodegenerativ...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2018-05, Vol.185 (5), p.276-25, Article 276 |
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| creator | Farzin, Leila Shamsipur, Mojtaba Samandari, Leila Sheibani, Shahab |
| description | This review (with 340 refs) focuses on methods for specific and sensitive detection of metabolites for diagnostic purposes, with particular emphasis on electrochemical nanomaterial-based sensors. It also covers novel candidate metabolites as potential biomarkers for diseases such as neurodegenerative diseases, autism spectrum disorder and hepatitis. Following an introduction into the field of metabolic biomarkers, a first major section classifies electrochemical biosensors according to the bioreceptor type (enzymatic, immuno, apta and peptide based sensors). A next section covers applications of nanomaterials in electrochemical biosensing (with subsections on the classification of nanomaterials, electrochemical approaches for signal generation and amplification using nanomaterials, and on nanomaterials as tags). A next large sections treats candidate metabolic biomarkers for diagnosis of diseases (in the context with metabolomics), with subsections on biomarkers for neurodegenerative diseases, autism spectrum disorder and hepatitis. The Conclusion addresses current challenges and future perspectives.
Graphical abstract
This review focuses on the recent developments in electrochemical biosensors based on the use of nanomaterials for the detection of metabolic biomarkers. It covers the critical metabolites for some diseases such as neurodegenerative diseases, autism spectrum disorder and hepatitis. |
| doi_str_mv | 10.1007/s00604-018-2820-8 |
| format | Article |
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Graphical abstract
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Graphical abstract
This review focuses on the recent developments in electrochemical biosensors based on the use of nanomaterials for the detection of metabolic biomarkers. 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Graphical abstract
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| subjects | Analytical Chemistry Autism Biological markers Biomarkers Biosensors Characterization and Evaluation of Materials Chemical sensors Chemistry Chemistry and Materials Science Diagnostic systems Electric properties Enzymes Hepatitis Medical equipment Metabolism Metabolites Microengineering Nanochemistry Nanomaterials Nanotechnology Nervous system diseases Neurological diseases Pervasive developmental disorders Physiological apparatus Review Article Signal generation |
| title | Advances in the design of nanomaterial-based electrochemical affinity and enzymatic biosensors for metabolic biomarkers: A review |
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