Five‐year outcomes in kidney transplant patients randomized to everolimus with cyclosporine withdrawal or low‐exposure cyclosporine versus standard therapy

HERAKLES was a 1‐year randomized, multicenter trial. Patients were randomized at 3 months after kidney transplantation to remain on cyclosporine‐based therapy, switch to everolimus without a calcineurin inhibitor (CNI), or switch to everolimus with low‐exposure cyclosporine. Overall, 417 of 497 (83....

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Veröffentlicht in:	American journal of transplantation 2018-12, Vol.18 (12), p.2965-2976
Hauptverfasser:	Sommerer, Claudia, Duerr, Michael, Witzke, Oliver, Lehner, Frank, Arns, Wolfgang, Kliem, Volker, Ackermann, Daniel, Guba, Markus, Jacobi, Johannes, Hauser, Ingeborg A., Stahl, Rolf, Reinke, Petra, Rath, Thomas, Veit, Justyna, Mehrabi, Arianeb, Porstner, Martina, Budde, Klemens, Mühlfeld, Anja, Babel, Nina, Schäffner, Elke, Hugo, Christian, Pressmar, Katharina, Pietruck, Frank, Kribben, Andreas, Asbe‐Vollkopf, Aida, Pisarski, Przemyslaw, Drognitz, Oliver, Thaiss, Friedrich, Klempnauer, Jürgen, Weithofer, Peter, Zeier, Martin, Huppertz, Andrea, Hackenberg, Ruth, Nitschke, Martin, Jauch, Karl‐Günter, Andrassy, Joachim, Stangl, Manfred, Thorban, Stefan, Banas, Bernhard, Frey, Felix, Vogt, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biopsy Calcineurin Calcineurin inhibitors Clinical outcomes clinical research/practice Clinical trials Cyclosporine - therapeutic use Cyclosporins Everolimus - therapeutic use Evidence-based medicine Female Follow-Up Studies Glomerular Filtration Rate Graft rejection Graft Rejection - drug therapy Graft Rejection - etiology Graft Survival - drug effects Humans immunosuppressant ‐ calcineurin inhibitor: cyclosporine A (CsA) immunosuppressant ‐ mechanistic target of rapamycin (mTOR) immunosuppressant ‐ mechanistic target of rapamycin: everolimus Immunosuppression immunosuppression/immune modulation Immunosuppressive Agents - therapeutic use Immunotherapy Inhibitor drugs Kidney diseases Kidney Failure, Chronic - surgery Kidney Function Tests Kidney transplantation Kidney Transplantation - adverse effects kidney transplantation/nephrology Kidney transplants Male Middle Aged Postoperative Complications Prognosis Prospective Studies Renal function Risk Factors Transplants & implants Withholding Treatment Young Adult
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