MMP-12 activates protease-activated receptor-1, upregulates placenta growth factor, and leads to pulmonary emphysema

Because of the expansion of aging and smoking populations, chronic obstructive pulmonary disease (COPD) is predicted to be the third leading cause of death worldwide in 2030. Therefore, it is pertinent to develop effective therapy to improve management for COPD. Cigarette smoke-mediated protease-ant...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2018-09, Vol.315 (3), p.L432-L442
Hauptverfasser:	Hou, Hsin-Han, Wang, Hao-Chien, Cheng, Shih-Lung, Chen, Yen-Fu, Lu, Kai-Zen, Yu, Chong-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Apoptosis Caspase Caspase-3 Caspase-9 Chronic obstructive pulmonary disease Cigarette smoke EGR-1 protein Elastase Emphysema Epithelial cells Growth factors Infiltration Leukocytes (neutrophilic) Lung diseases Macrophages Matrix metalloproteinases Obstructive lung disease Pathogenesis Placenta Placenta growth factor Protease Proteases Proteinase-activated receptor 1 Proteins Signaling Smoke Smoking
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