Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner

CSF-1 is a hemopoietic growth factor, which plays an essential role in macrophage and osteoclast development. Alternative splice variants of CSF-1 are synthesized as soluble or membrane-anchored molecules, although membrane CSF-1 (mCSF-1) can be cleaved from the cell membrane to become soluble CSF-1...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-11, Vol.179 (10), p.6715-6724
Hauptverfasser:	Horiuchi, Keisuke, Miyamoto, Takeshi, Takaishi, Hironari, Hakozaki, Akihiro, Kosaki, Naoto, Miyauchi, Yoshiteru, Furukawa, Mitsuru, Takito, Jiro, Kaneko, Hironori, Matsuzaki, Kenichiro, Morioka, Hideo, Blobel, Carl P, Toyama, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - antagonists & inhibitors ADAM Proteins - metabolism ADAM17 Protein Alternative Splicing - drug effects Alternative Splicing - physiology Animals Carcinogens - pharmacology Cell Survival - drug effects Cell Survival - physiology Cercopithecus aethiops Clathrin - metabolism COS Cells Dipeptides - pharmacology Endocytosis - physiology Macrophage Colony-Stimulating Factor - metabolism Macrophages - metabolism Membrane Proteins - metabolism Mice Osteoclasts - metabolism Phorbol Esters - pharmacology Protease Inhibitors - pharmacology Protein Structure, Tertiary - physiology Tissue Inhibitor of Metalloproteinase-3 - metabolism
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