Acute iron poisoning in adult female
We report a case of a 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy (within 20 days, the patient received a total dose of 4 g Fe+2 orally and 700 mg Fe+2 iv and im), and developed clinical manifestations characteristic of acute iron poisoning. Initial gastro...
Gespeichert in:
| Veröffentlicht in: | Human & experimental toxicology 2007-08, Vol.26 (8), p.663-666 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 666 |
|---|---|
| container_issue | 8 |
| container_start_page | 663 |
| container_title | Human & experimental toxicology |
| container_volume | 26 |
| creator | Skoczynska, A. Kwiecinska, D. Kielbinski, M. Łukaszewski, M. |
| description | We report a case of a 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy (within 20 days, the patient received a total dose of 4 g Fe+2 orally and 700 mg Fe+2 iv and im), and developed clinical manifestations characteristic of acute iron poisoning. Initial gastrointestinal symptoms and hypotension were followed by signs of mitochondrial toxicity: high leucocytosis, shock, multi-organ failure and disseminated intravascular coagulation. We discuss the difficulties in diagnosing acute iron poisoning. The initial low total iron blood capacity and high ferritin level, as well as the typical sequence of symptoms, supported the diagnosis. The patient avoided fatal consequences, probably due to the administration of iron doses over an extended period of time. However, cumulative effects led to the apparent iron toxicity. After 2 weeks of treatment, the patient was discharged from hospital in good condition. Human & Experimental Toxicology (2007) 26, 663-666 |
| doi_str_mv | 10.1177/0960327107071854 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_miscellaneous_20340930</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0960327107071854</sage_id><sourcerecordid>20340930</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-12fbec21428a99b7950e39111d9f15244dd11024f767133ae47295a2ae76418a3</originalsourceid><addsrcrecordid>eNp10M9LwzAUB_AgipvTuycpot6q7-VH0xzH8BcMvOi5ZG06MtpmJu3B_34ZKwwGnnJ4n_fy3peQW4RnRClfQGXAqESQIDEX_IxMkUuZggJ2Tqb7crqvT8hVCBsAyJTASzJBmedcCT4lD_Ny6E1iveuSrbPBdbZbJ7ZLdDU0fVKbVjfmmlzUugnmZnxn5Oft9XvxkS6_3j8X82Va8kz0KdJ6ZUqKnOZaqZVUAgxTiFipGgXlvKoQgfJaZhIZ04ZLqoSm2siMY67ZjDwd5m69-x1M6IvWhtI0je6MG0JBgXFQDCK8P4EbN_gu7lZQCjlyzkREcECldyF4Uxdbb1vt_wqEYh9fcRpfbLkb5w6r1lTHhjGvCB5HoEOpm9rrrrTh6OK1IFQWXXpwQa_Ncbl_P94Bx2J_5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220814435</pqid></control><display><type>article</type><title>Acute iron poisoning in adult female</title><source>Sage Journals GOLD Open Access 2024</source><creator>Skoczynska, A. ; Kwiecinska, D. ; Kielbinski, M. ; Łukaszewski, M.</creator><creatorcontrib>Skoczynska, A. ; Kwiecinska, D. ; Kielbinski, M. ; Łukaszewski, M.</creatorcontrib><description>We report a case of a 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy (within 20 days, the patient received a total dose of 4 g Fe+2 orally and 700 mg Fe+2 iv and im), and developed clinical manifestations characteristic of acute iron poisoning. Initial gastrointestinal symptoms and hypotension were followed by signs of mitochondrial toxicity: high leucocytosis, shock, multi-organ failure and disseminated intravascular coagulation. We discuss the difficulties in diagnosing acute iron poisoning. The initial low total iron blood capacity and high ferritin level, as well as the typical sequence of symptoms, supported the diagnosis. The patient avoided fatal consequences, probably due to the administration of iron doses over an extended period of time. However, cumulative effects led to the apparent iron toxicity. After 2 weeks of treatment, the patient was discharged from hospital in good condition. Human & Experimental Toxicology (2007) 26, 663-666</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327107071854</identifier><identifier>PMID: 17884954</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acute Disease ; Administration, Oral ; Adult ; Anemia ; Anemia - drug therapy ; Biological and medical sciences ; Case studies ; Chemical and industrial products toxicology. Toxic occupational diseases ; Disseminated Intravascular Coagulation - chemically induced ; Drug Administration Schedule ; Female ; Gastrointestinal Diseases - chemically induced ; Hematinics - administration & dosage ; Hematinics - poisoning ; Humans ; Hypotension - chemically induced ; Injections, Intramuscular ; Injections, Intravenous ; Iron ; Iron Compounds - administration & dosage ; Iron Compounds - poisoning ; Leukocytosis - chemically induced ; Medical sciences ; Metals and various inorganic compounds ; Mitochondria - drug effects ; Multiple Organ Failure - chemically induced ; Poisoning ; Poisoning - complications ; Poisoning - diagnosis ; Poisoning - therapy ; Toxicology ; Treatment Outcome ; Women</subject><ispartof>Human & experimental toxicology, 2007-08, Vol.26 (8), p.663-666</ispartof><rights>2007 INIST-CNRS</rights><rights>SAGE Publications © Aug 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-12fbec21428a99b7950e39111d9f15244dd11024f767133ae47295a2ae76418a3</citedby><cites>FETCH-LOGICAL-c465t-12fbec21428a99b7950e39111d9f15244dd11024f767133ae47295a2ae76418a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327107071854$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327107071854$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21946,27832,27903,27904,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327107071854?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19110596$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17884954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skoczynska, A.</creatorcontrib><creatorcontrib>Kwiecinska, D.</creatorcontrib><creatorcontrib>Kielbinski, M.</creatorcontrib><creatorcontrib>Łukaszewski, M.</creatorcontrib><title>Acute iron poisoning in adult female</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>We report a case of a 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy (within 20 days, the patient received a total dose of 4 g Fe+2 orally and 700 mg Fe+2 iv and im), and developed clinical manifestations characteristic of acute iron poisoning. Initial gastrointestinal symptoms and hypotension were followed by signs of mitochondrial toxicity: high leucocytosis, shock, multi-organ failure and disseminated intravascular coagulation. We discuss the difficulties in diagnosing acute iron poisoning. The initial low total iron blood capacity and high ferritin level, as well as the typical sequence of symptoms, supported the diagnosis. The patient avoided fatal consequences, probably due to the administration of iron doses over an extended period of time. However, cumulative effects led to the apparent iron toxicity. After 2 weeks of treatment, the patient was discharged from hospital in good condition. Human & Experimental Toxicology (2007) 26, 663-666</description><subject>Acute Disease</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Anemia</subject><subject>Anemia - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Case studies</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Disseminated Intravascular Coagulation - chemically induced</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Gastrointestinal Diseases - chemically induced</subject><subject>Hematinics - administration & dosage</subject><subject>Hematinics - poisoning</subject><subject>Humans</subject><subject>Hypotension - chemically induced</subject><subject>Injections, Intramuscular</subject><subject>Injections, Intravenous</subject><subject>Iron</subject><subject>Iron Compounds - administration & dosage</subject><subject>Iron Compounds - poisoning</subject><subject>Leukocytosis - chemically induced</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mitochondria - drug effects</subject><subject>Multiple Organ Failure - chemically induced</subject><subject>Poisoning</subject><subject>Poisoning - complications</subject><subject>Poisoning - diagnosis</subject><subject>Poisoning - therapy</subject><subject>Toxicology</subject><subject>Treatment Outcome</subject><subject>Women</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp10M9LwzAUB_AgipvTuycpot6q7-VH0xzH8BcMvOi5ZG06MtpmJu3B_34ZKwwGnnJ4n_fy3peQW4RnRClfQGXAqESQIDEX_IxMkUuZggJ2Tqb7crqvT8hVCBsAyJTASzJBmedcCT4lD_Ny6E1iveuSrbPBdbZbJ7ZLdDU0fVKbVjfmmlzUugnmZnxn5Oft9XvxkS6_3j8X82Va8kz0KdJ6ZUqKnOZaqZVUAgxTiFipGgXlvKoQgfJaZhIZ04ZLqoSm2siMY67ZjDwd5m69-x1M6IvWhtI0je6MG0JBgXFQDCK8P4EbN_gu7lZQCjlyzkREcECldyF4Uxdbb1vt_wqEYh9fcRpfbLkb5w6r1lTHhjGvCB5HoEOpm9rrrrTh6OK1IFQWXXpwQa_Ncbl_P94Bx2J_5Q</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Skoczynska, A.</creator><creator>Kwiecinska, D.</creator><creator>Kielbinski, M.</creator><creator>Łukaszewski, M.</creator><general>SAGE Publications</general><general>Arnold</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>SOI</scope></search><sort><creationdate>20070801</creationdate><title>Acute iron poisoning in adult female</title><author>Skoczynska, A. ; Kwiecinska, D. ; Kielbinski, M. ; Łukaszewski, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-12fbec21428a99b7950e39111d9f15244dd11024f767133ae47295a2ae76418a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acute Disease</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Anemia</topic><topic>Anemia - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Case studies</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Disseminated Intravascular Coagulation - chemically induced</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Gastrointestinal Diseases - chemically induced</topic><topic>Hematinics - administration & dosage</topic><topic>Hematinics - poisoning</topic><topic>Humans</topic><topic>Hypotension - chemically induced</topic><topic>Injections, Intramuscular</topic><topic>Injections, Intravenous</topic><topic>Iron</topic><topic>Iron Compounds - administration & dosage</topic><topic>Iron Compounds - poisoning</topic><topic>Leukocytosis - chemically induced</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mitochondria - drug effects</topic><topic>Multiple Organ Failure - chemically induced</topic><topic>Poisoning</topic><topic>Poisoning - complications</topic><topic>Poisoning - diagnosis</topic><topic>Poisoning - therapy</topic><topic>Toxicology</topic><topic>Treatment Outcome</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skoczynska, A.</creatorcontrib><creatorcontrib>Kwiecinska, D.</creatorcontrib><creatorcontrib>Kielbinski, M.</creatorcontrib><creatorcontrib>Łukaszewski, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Skoczynska, A.</au><au>Kwiecinska, D.</au><au>Kielbinski, M.</au><au>Łukaszewski, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute iron poisoning in adult female</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>26</volume><issue>8</issue><spage>663</spage><epage>666</epage><pages>663-666</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>We report a case of a 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy (within 20 days, the patient received a total dose of 4 g Fe+2 orally and 700 mg Fe+2 iv and im), and developed clinical manifestations characteristic of acute iron poisoning. Initial gastrointestinal symptoms and hypotension were followed by signs of mitochondrial toxicity: high leucocytosis, shock, multi-organ failure and disseminated intravascular coagulation. We discuss the difficulties in diagnosing acute iron poisoning. The initial low total iron blood capacity and high ferritin level, as well as the typical sequence of symptoms, supported the diagnosis. The patient avoided fatal consequences, probably due to the administration of iron doses over an extended period of time. However, cumulative effects led to the apparent iron toxicity. After 2 weeks of treatment, the patient was discharged from hospital in good condition. Human & Experimental Toxicology (2007) 26, 663-666</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17884954</pmid><doi>10.1177/0960327107071854</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0960-3271 |
| ispartof | Human & experimental toxicology, 2007-08, Vol.26 (8), p.663-666 |
| issn | 0960-3271 1477-0903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20340930 |
| source | Sage Journals GOLD Open Access 2024 |
| subjects | Acute Disease Administration, Oral Adult Anemia Anemia - drug therapy Biological and medical sciences Case studies Chemical and industrial products toxicology. Toxic occupational diseases Disseminated Intravascular Coagulation - chemically induced Drug Administration Schedule Female Gastrointestinal Diseases - chemically induced Hematinics - administration & dosage Hematinics - poisoning Humans Hypotension - chemically induced Injections, Intramuscular Injections, Intravenous Iron Iron Compounds - administration & dosage Iron Compounds - poisoning Leukocytosis - chemically induced Medical sciences Metals and various inorganic compounds Mitochondria - drug effects Multiple Organ Failure - chemically induced Poisoning Poisoning - complications Poisoning - diagnosis Poisoning - therapy Toxicology Treatment Outcome Women |
| title | Acute iron poisoning in adult female |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T04%3A27%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20iron%20poisoning%20in%20adult%20female&rft.jtitle=Human%20&%20experimental%20toxicology&rft.au=Skoczynska,%20A.&rft.date=2007-08-01&rft.volume=26&rft.issue=8&rft.spage=663&rft.epage=666&rft.pages=663-666&rft.issn=0960-3271&rft.eissn=1477-0903&rft_id=info:doi/10.1177/0960327107071854&rft_dat=%3Cproquest_AFRWT%3E20340930%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220814435&rft_id=info:pmid/17884954&rft_sage_id=10.1177_0960327107071854&rfr_iscdi=true |