Large Animal Models of Traumatic Injury to the Immature Brain
Large animal models have been used much less frequently than rodent models to study traumatic brain injury. However, large animal models offer distinct advantages in replicating specific mechanisms, morphology and maturational stages relevant to age-dependent injury responses. This paper reviews how...
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| Veröffentlicht in: | Developmental neuroscience 2006-01, Vol.28 (4-5), p.380-387 |
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| container_title | Developmental neuroscience |
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| creator | Duhaime, Ann-Christine |
| description | Large animal models have been used much less frequently than rodent models to study traumatic brain injury. However, large animal models offer distinct advantages in replicating specific mechanisms, morphology and maturational stages relevant to age-dependent injury responses. This paper reviews how each of these features is relevant in matching a model to a particular scientific question and discusses various scaling strategies, advantages and disadvantages of large animal models for studying traumatic brain injury in infants and children. Progress to date and future directions are outlined. |
| doi_str_mv | 10.1159/000094164 |
| format | Article |
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| identifier | ISSN: 0378-5866 |
| ispartof | Developmental neuroscience, 2006-01, Vol.28 (4-5), p.380-387 |
| issn | 0378-5866 1421-9859 |
| language | eng |
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| source | MEDLINE; Karger Journals |
| subjects | Aging - physiology Animals Basic Science Research Biomechanical Phenomena Brain - growth & development Brain - pathology Brain - physiopathology Brain Injuries - physiopathology Child Diffuse Axonal Injury - physiopathology Disease Models, Animal Head Injuries, Closed - physiopathology Humans Immunohistochemistry - standards Neurosurgical Procedures - methods Neurosurgical Procedures - standards Sus scrofa - growth & development Sus scrofa - physiology Sus scrofa - surgery Veterinary Medicine - standards |
| title | Large Animal Models of Traumatic Injury to the Immature Brain |
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