Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents

The synthesis of two groups of structure hybrids comprising basically the antipyrine moiety attached to either polysubstituted thiazole or 2,5-disubstituted-1,3,4-thiadiazole counterparts through various linkages is described. Twelve compounds were evaluated for their anti-inflammatory activity, ulc...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2009-01, Vol.17 (2), p.882-895
Hauptverfasser:	Rostom, Sherif A.F., El-Ashmawy, Ibrahim M., Abd El Razik, Heba A., Badr, Mona H., Ashour, Hayam M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4-Thiadiazoles Acute toxicity Analgesic activity Analgesics Analgesics - chemical synthesis Analgesics - pharmacology Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial activity Antipyrine Antipyrine - analogs & derivatives Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Drug Design Drug Evaluation, Preclinical General aspects Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Structure-Activity Relationship Thiadiazoles - chemical synthesis Thiadiazoles - pharmacology Thiazoles Thiazoles - chemical synthesis Thiazoles - pharmacology Ulcerogenic effect
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