Considerations of nano-QSAR/QSPR models for nanopesticide risk assessment within the European legislative framework
The European market for pesticides is currently legislated through the well-developed Regulation (EC) No. 1107/2009. This regulation promotes the competitiveness of European agriculture, recognizing the necessity of safe pesticides for human and animal health and the environment to protect crops aga...
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Veröffentlicht in: | The Science of the total environment 2018-09, Vol.634, p.1530-1539 |
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description | The European market for pesticides is currently legislated through the well-developed Regulation (EC) No. 1107/2009. This regulation promotes the competitiveness of European agriculture, recognizing the necessity of safe pesticides for human and animal health and the environment to protect crops against pests, diseases and weeds. In this sense, nanotechnology can provide a tremendous opportunity to achieve a more rational use of pesticides. However, the lack of information regarding nanopesticides and their fate and behavior in the environment and their effects on human and animal health is inhibiting rapid nanopesticide incorporation into European Union agriculture.
This review analyzes the recent state of knowledge on nanopesticide risk assessment, highlighting the challenges that need to be overcame to accelerate the arrival of these new tools for plant protection to European agricultural professionals. Novel nano-Quantitative Structure-Activity/Structure-Property Relationship (nano-QSAR/QSPR) tools for risk assessment are analyzed, including modeling methods and validation procedures towards the potential of these computational instruments to meet the current requirements for authorization of nanoformulations. Future trends on these issues, of pressing importance within the context of the current European pesticide legislative framework, are also discussed. Standard protocols to make high-quality and well-described datasets for the series of related but differently sized nanoparticles/nanopesticides are required.
[Display omitted]
•European legislation framework of nanopesticides is analyzed•Physicochemical and eco/toxicological considerations are highlighted•Current nano-QSAR/QSPR modeling methods and validation requirements are revised•Outlook for priorities in order to achieve nanopesticides safe use are pointed out |
doi_str_mv | 10.1016/j.scitotenv.2018.04.033 |
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This review analyzes the recent state of knowledge on nanopesticide risk assessment, highlighting the challenges that need to be overcame to accelerate the arrival of these new tools for plant protection to European agricultural professionals. Novel nano-Quantitative Structure-Activity/Structure-Property Relationship (nano-QSAR/QSPR) tools for risk assessment are analyzed, including modeling methods and validation procedures towards the potential of these computational instruments to meet the current requirements for authorization of nanoformulations. Future trends on these issues, of pressing importance within the context of the current European pesticide legislative framework, are also discussed. Standard protocols to make high-quality and well-described datasets for the series of related but differently sized nanoparticles/nanopesticides are required.
[Display omitted]
•European legislation framework of nanopesticides is analyzed•Physicochemical and eco/toxicological considerations are highlighted•Current nano-QSAR/QSPR modeling methods and validation requirements are revised•Outlook for priorities in order to achieve nanopesticides safe use are pointed out</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2018.04.033</identifier><identifier>PMID: 29710651</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Descriptors ; Endpoints ; nano-Quantitative Structure-Activity/Structure-Property Relationship ; Nanoformulation ; Regulation (EC) No. 1107/2009 ; Validation</subject><ispartof>The Science of the total environment, 2018-09, Vol.634, p.1530-1539</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-519abbef288a01587278616c09350edc028101566c3a63dc2c997f3c74ba6ed93</citedby><cites>FETCH-LOGICAL-c437t-519abbef288a01587278616c09350edc028101566c3a63dc2c997f3c74ba6ed93</cites><orcidid>0000-0001-7663-2846 ; 0000-0002-5911-792X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2018.04.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29710651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villaverde, Juan José</creatorcontrib><creatorcontrib>Sevilla-Morán, Beatriz</creatorcontrib><creatorcontrib>López-Goti, Carmen</creatorcontrib><creatorcontrib>Alonso-Prados, José Luis</creatorcontrib><creatorcontrib>Sandín-España, Pilar</creatorcontrib><title>Considerations of nano-QSAR/QSPR models for nanopesticide risk assessment within the European legislative framework</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>The European market for pesticides is currently legislated through the well-developed Regulation (EC) No. 1107/2009. This regulation promotes the competitiveness of European agriculture, recognizing the necessity of safe pesticides for human and animal health and the environment to protect crops against pests, diseases and weeds. In this sense, nanotechnology can provide a tremendous opportunity to achieve a more rational use of pesticides. However, the lack of information regarding nanopesticides and their fate and behavior in the environment and their effects on human and animal health is inhibiting rapid nanopesticide incorporation into European Union agriculture.
This review analyzes the recent state of knowledge on nanopesticide risk assessment, highlighting the challenges that need to be overcame to accelerate the arrival of these new tools for plant protection to European agricultural professionals. Novel nano-Quantitative Structure-Activity/Structure-Property Relationship (nano-QSAR/QSPR) tools for risk assessment are analyzed, including modeling methods and validation procedures towards the potential of these computational instruments to meet the current requirements for authorization of nanoformulations. Future trends on these issues, of pressing importance within the context of the current European pesticide legislative framework, are also discussed. Standard protocols to make high-quality and well-described datasets for the series of related but differently sized nanoparticles/nanopesticides are required.
[Display omitted]
•European legislation framework of nanopesticides is analyzed•Physicochemical and eco/toxicological considerations are highlighted•Current nano-QSAR/QSPR modeling methods and validation requirements are revised•Outlook for priorities in order to achieve nanopesticides safe use are pointed out</description><subject>Descriptors</subject><subject>Endpoints</subject><subject>nano-Quantitative Structure-Activity/Structure-Property Relationship</subject><subject>Nanoformulation</subject><subject>Regulation (EC) No. 1107/2009</subject><subject>Validation</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkM1uEzEURi0EomngFcBLNjO1xzP-WUZRC5UqQVtYW47nDnU6Mw6-TireHoeUbvHGlny-714dQj5yVnPG5cW2Rh9yzDAf6oZxXbO2ZkK8Iguulak4a-RrsmCs1ZWRRp2Rc8QtK0dp_pacNUZxJju-ILiOM4YeksuhvGgc6OzmWN3er-4ubu-_3dEp9jAiHWL6-7MDzMGXBE0BH6lDBMQJ5kyfQn4IM80PQC_3qYBupiP8DDiW7gPQIbkJnmJ6fEfeDG5EeP98L8mPq8vv6y_VzdfP1-vVTeVboXLVceM2GxgarR3jnVaN0pJLz4zoGPSeNbq46KT0wknR-8YbowbhVbtxEnojluTTqXeX4q992dtOAT2Mo5sh7tE2xZjQinFeUHVCfYqICQa7S2Fy6bflzB6N2619MW6Pxi1r7TG_JB-eh-w3E_QvuX-KC7A6AcUiHAKkYxHMHvqQwGfbx_DfIX8AA8KYPw</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Villaverde, Juan José</creator><creator>Sevilla-Morán, Beatriz</creator><creator>López-Goti, Carmen</creator><creator>Alonso-Prados, José Luis</creator><creator>Sandín-España, Pilar</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7663-2846</orcidid><orcidid>https://orcid.org/0000-0002-5911-792X</orcidid></search><sort><creationdate>20180901</creationdate><title>Considerations of nano-QSAR/QSPR models for nanopesticide risk assessment within the European legislative framework</title><author>Villaverde, Juan José ; Sevilla-Morán, Beatriz ; López-Goti, Carmen ; Alonso-Prados, José Luis ; Sandín-España, Pilar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-519abbef288a01587278616c09350edc028101566c3a63dc2c997f3c74ba6ed93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Descriptors</topic><topic>Endpoints</topic><topic>nano-Quantitative Structure-Activity/Structure-Property Relationship</topic><topic>Nanoformulation</topic><topic>Regulation (EC) No. 1107/2009</topic><topic>Validation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villaverde, Juan José</creatorcontrib><creatorcontrib>Sevilla-Morán, Beatriz</creatorcontrib><creatorcontrib>López-Goti, Carmen</creatorcontrib><creatorcontrib>Alonso-Prados, José Luis</creatorcontrib><creatorcontrib>Sandín-España, Pilar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villaverde, Juan José</au><au>Sevilla-Morán, Beatriz</au><au>López-Goti, Carmen</au><au>Alonso-Prados, José Luis</au><au>Sandín-España, Pilar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Considerations of nano-QSAR/QSPR models for nanopesticide risk assessment within the European legislative framework</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>634</volume><spage>1530</spage><epage>1539</epage><pages>1530-1539</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>The European market for pesticides is currently legislated through the well-developed Regulation (EC) No. 1107/2009. This regulation promotes the competitiveness of European agriculture, recognizing the necessity of safe pesticides for human and animal health and the environment to protect crops against pests, diseases and weeds. In this sense, nanotechnology can provide a tremendous opportunity to achieve a more rational use of pesticides. However, the lack of information regarding nanopesticides and their fate and behavior in the environment and their effects on human and animal health is inhibiting rapid nanopesticide incorporation into European Union agriculture.
This review analyzes the recent state of knowledge on nanopesticide risk assessment, highlighting the challenges that need to be overcame to accelerate the arrival of these new tools for plant protection to European agricultural professionals. Novel nano-Quantitative Structure-Activity/Structure-Property Relationship (nano-QSAR/QSPR) tools for risk assessment are analyzed, including modeling methods and validation procedures towards the potential of these computational instruments to meet the current requirements for authorization of nanoformulations. Future trends on these issues, of pressing importance within the context of the current European pesticide legislative framework, are also discussed. Standard protocols to make high-quality and well-described datasets for the series of related but differently sized nanoparticles/nanopesticides are required.
[Display omitted]
•European legislation framework of nanopesticides is analyzed•Physicochemical and eco/toxicological considerations are highlighted•Current nano-QSAR/QSPR modeling methods and validation requirements are revised•Outlook for priorities in order to achieve nanopesticides safe use are pointed out</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29710651</pmid><doi>10.1016/j.scitotenv.2018.04.033</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7663-2846</orcidid><orcidid>https://orcid.org/0000-0002-5911-792X</orcidid></addata></record> |
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subjects | Descriptors Endpoints nano-Quantitative Structure-Activity/Structure-Property Relationship Nanoformulation Regulation (EC) No. 1107/2009 Validation |
title | Considerations of nano-QSAR/QSPR models for nanopesticide risk assessment within the European legislative framework |
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