Transient Increase of Cytokines in the Acute Ischemic Tissue is Beneficial to Cell-Based Therapeutic Angiogenesis

Background Implantation of bone marrow cells (BMCs) is a treatment of ischemic disease. It is well known that many inflammatory cytokines are released in ischemic tissue, especially in the acute phase, so in the present study it was investigated if the transient increase of cytokines in the acute is...

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Veröffentlicht in:	Circulation Journal 2008, Vol.72(12), pp.2075-2080
Hauptverfasser:	Qin, Shu-Lan, Li, Tao-Sheng, Kubo, Masayuki, Ohshima, Mako, Furutani, Akira, Hamano, Kimikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute ischemic tissue Angiogenesis Animals Bone marrow cells Bone Marrow Cells - metabolism Bone Marrow Transplantation Cell Adhesion Cell Movement Cell Survival Cells, Cultured Chemokine CCL2 - metabolism Chronic Disease Cytokines Cytokines - metabolism Disease Models, Animal Fibroblast Growth Factor 2 - metabolism Green Fluorescent Proteins - genetics Hindlimb Interleukin-1beta - metabolism Ischemia - immunology Ischemia - metabolism Ischemia - physiopathology Ischemia - surgery Male Mice Mice, Inbred C57BL Mice, Transgenic Muscle Proteins - metabolism Muscle, Skeletal - blood supply Muscle, Skeletal - immunology Muscle, Skeletal - metabolism Neovascularization, Physiologic Regional Blood Flow Time Factors Up-Regulation
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