Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling

Cerivastatin (CER) was withdrawn from the world market because of lethal rhabdomyolysis. Coadministrations of CER and cyclosporine A (CsA) or gemfibrozil (GEM) have been reported to increase the CER blood concentration. CsA is an inhibitor of organic anion transporting polypeptide (OATP)1B1 and CYP3...

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Veröffentlicht in:	Drug metabolism and disposition 2018-07, Vol.46 (7), p.924-933
Hauptverfasser:	Yao, Yoshiaki, Toshimoto, Kota, Kim, Soo-Jin, Yoshikado, Takashi, Sugiyama, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood levels Cerivastatin Computer simulation Construction standards Cyclosporins Cytochrome Cytochromes Drug dependence Gemfibrozil Inhibitors Metabolism Newton methods Organic anion transporting polypeptide Parameter sensitivity Pharmacokinetics Pharmacology Quantitative analysis Rhabdomyolysis Sensitivity Sensitivity analysis
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