Improving Viscosity and Stability of a Highly Concentrated Monoclonal Antibody Solution with Concentrated Proline

Purpose To explain the effects of the osmolyte proline on the protein-protein interactions (PPI), viscosity and stability of highly concentrated antibody solutions in contrast to other neutral osmolytes. Methods The viscosity of ~225 mg/mL mAb solutions was measured with proline, glycine and trehalo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical research 2018-07, Vol.35 (7), p.133-14, Article 133
Hauptverfasser:	Hung, Jessica J., Dear, Barton J., Dinin, Aileen K., Borwankar, Ameya U., Mehta, Sumarth K., Truskett, Thomas T., Johnston, Keith P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies, Monoclonal - analysis Antibodies, Monoclonal - chemistry Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical - methods Chromatography Diffusion coefficient Diffusion rate Drug Stability Electrostatic properties Formulations Glycine Histidine Hydrophobicity Light scattering Medical Law Monoclonal antibodies Osmolarity pH effects Pharmaceutical Solutions - analysis Pharmaceutical Solutions - chemistry Pharmacology/Toxicology Pharmacy Photon correlation spectroscopy Proline Proline - analysis Proline - chemistry Protein interaction Protein-protein interactions Proteins Pyrrolidine Research Paper Self-association Size exclusion chromatography Trehalose Turbidity Viscosity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!