Sulforaphane Upregulates the Heat Shock Protein Co‐Chaperone CHIP and Clears Amyloid‐β and Tau in a Mouse Model of Alzheimer's Disease

Scope Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables. Here, the authors investigate whether sulforaphane modulates the production of amyloid‐β (Aβ) and tau, the two main pathological factors in Alzheimer's disease (AD). Methods and results A triple transgenic mouse...

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Veröffentlicht in:	Molecular nutrition & food research 2018-06, Vol.62 (12), p.e1800240-n/a
Hauptverfasser:	Lee, Siyoung, Choi, Bo‐Ryoung, Kim, Jisung, LaFerla, Frank M., Park, Jung Han Yoon, Han, Jung‐Soo, Lee, Ki Won, Kim, Jiyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid precursor protein amyloid‐β Animals Cerebral Cortex - drug effects Cerebral Cortex - metabolism CHIP Disease Models, Animal Fear conditioning Female Gene expression Heat shock proteins Hippocampus - drug effects Hippocampus - metabolism HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Isothiocyanate Isothiocyanates - pharmacology Memory Memory Disorders - drug therapy Metabolism Mice Mice, Transgenic Neurodegenerative diseases Neurons - drug effects Neurons - metabolism Neurons - pathology Object recognition Rodents Sulforaphane tau Tau protein tau Proteins - metabolism Transgenic mice Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Up-Regulation
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