Programmable Hydrogel Ionic Circuits for Biologically Matched Electronic Interfaces
The increased need for wearable and implantable medical devices has driven the demand for electronics that interface with living systems. Current bioelectronic systems have not fully resolved mismatches between engineered circuits and biological systems, including the resulting pain and damage to bi...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2018-06, Vol.30 (25), p.e1800598-n/a |
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| creator | Zhao, Siwei Tseng, Peter Grasman, Jonathan Wang, Yu Li, Wenyi Napier, Bradley Yavuz, Burcin Chen, Ying Howell, Laurel Rincon, Javier Omenetto, Fiorenzo G. Kaplan, David L. |
| description | The increased need for wearable and implantable medical devices has driven the demand for electronics that interface with living systems. Current bioelectronic systems have not fully resolved mismatches between engineered circuits and biological systems, including the resulting pain and damage to biological tissues. Here, salt/poly(ethylene glycol) (PEG) aqueous two‐phase systems are utilized to generate programmable hydrogel ionic circuits. High‐conductivity salt‐solution patterns are stably encapsulated within PEG hydrogel matrices using salt/PEG phase separation, which route ionic current with high resolution and enable localized delivery of electrical stimulation. This strategy allows designer electronics that match biological systems, including transparency, stretchability, complete aqueous‐based connective interface, distribution of ionic electrical signals between engineered and biological systems, and avoidance of tissue damage from electrical stimulation. The potential of such systems is demonstrated by generating light‐emitting diode (LED)‐based displays, skin‐mounted electronics, and stimulators that deliver localized current to in vitro neuron cultures and muscles in vivo with reduced adverse effects. Such electronic platforms may form the basis of future biointegrated electronic systems.
Programmable hydrogel ionic circuits completely composed of salt, water, and biofriendly hydrogels are developed based on salt/poly(ethylene glycol) aqueous two‐phase systems. Such systems enable designer electronics that match the properties of biological systems and route high‐resolution ionic electrical signals between engineered and living systems while avoiding tissue damage. Such platforms may form the basis of future biointegrated electronic systems. |
| doi_str_mv | 10.1002/adma.201800598 |
| format | Article |
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Programmable hydrogel ionic circuits completely composed of salt, water, and biofriendly hydrogels are developed based on salt/poly(ethylene glycol) aqueous two‐phase systems. Such systems enable designer electronics that match the properties of biological systems and route high‐resolution ionic electrical signals between engineered and living systems while avoiding tissue damage. Such platforms may form the basis of future biointegrated electronic systems.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201800598</identifier><identifier>PMID: 29717798</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>aqueous two‐phase systems ; Biocompatible Materials ; Bioelectricity ; bioelectronics ; Circuits ; Electric power distribution ; Electrical resistivity ; Electronic systems ; Electronics ; Hydrogel, Polyethylene Glycol Dimethacrylate ; Hydrogels ; Hydrogels - chemistry ; ionic circuits ; Ions ; Light emitting diodes ; Medical devices ; Medical electronics ; Muscles ; Pain ; Phase separation ; poly(ethylene glycol) ; Polyethylene glycol ; Polyethylene Glycols ; Prostheses and Implants ; Skin ; Stimulation ; Stimulators ; Stretchability ; Surgical implants ; Tissues</subject><ispartof>Advanced materials (Weinheim), 2018-06, Vol.30 (25), p.e1800598-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4768-bfe90dd6ec152cd4ff0acd9739e2f0a1b756ba4a0edca02d9821d988f7cddb6c3</citedby><cites>FETCH-LOGICAL-c4768-bfe90dd6ec152cd4ff0acd9739e2f0a1b756ba4a0edca02d9821d988f7cddb6c3</cites><orcidid>0000-0002-9245-7774</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201800598$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201800598$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29717798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Siwei</creatorcontrib><creatorcontrib>Tseng, Peter</creatorcontrib><creatorcontrib>Grasman, Jonathan</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Li, Wenyi</creatorcontrib><creatorcontrib>Napier, Bradley</creatorcontrib><creatorcontrib>Yavuz, Burcin</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Howell, Laurel</creatorcontrib><creatorcontrib>Rincon, Javier</creatorcontrib><creatorcontrib>Omenetto, Fiorenzo G.</creatorcontrib><creatorcontrib>Kaplan, David L.</creatorcontrib><title>Programmable Hydrogel Ionic Circuits for Biologically Matched Electronic Interfaces</title><title>Advanced materials (Weinheim)</title><addtitle>Adv Mater</addtitle><description>The increased need for wearable and implantable medical devices has driven the demand for electronics that interface with living systems. Current bioelectronic systems have not fully resolved mismatches between engineered circuits and biological systems, including the resulting pain and damage to biological tissues. Here, salt/poly(ethylene glycol) (PEG) aqueous two‐phase systems are utilized to generate programmable hydrogel ionic circuits. High‐conductivity salt‐solution patterns are stably encapsulated within PEG hydrogel matrices using salt/PEG phase separation, which route ionic current with high resolution and enable localized delivery of electrical stimulation. This strategy allows designer electronics that match biological systems, including transparency, stretchability, complete aqueous‐based connective interface, distribution of ionic electrical signals between engineered and biological systems, and avoidance of tissue damage from electrical stimulation. The potential of such systems is demonstrated by generating light‐emitting diode (LED)‐based displays, skin‐mounted electronics, and stimulators that deliver localized current to in vitro neuron cultures and muscles in vivo with reduced adverse effects. Such electronic platforms may form the basis of future biointegrated electronic systems.
Programmable hydrogel ionic circuits completely composed of salt, water, and biofriendly hydrogels are developed based on salt/poly(ethylene glycol) aqueous two‐phase systems. Such systems enable designer electronics that match the properties of biological systems and route high‐resolution ionic electrical signals between engineered and living systems while avoiding tissue damage. Such platforms may form the basis of future biointegrated electronic systems.</description><subject>aqueous two‐phase systems</subject><subject>Biocompatible Materials</subject><subject>Bioelectricity</subject><subject>bioelectronics</subject><subject>Circuits</subject><subject>Electric power distribution</subject><subject>Electrical resistivity</subject><subject>Electronic systems</subject><subject>Electronics</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>ionic circuits</subject><subject>Ions</subject><subject>Light emitting diodes</subject><subject>Medical devices</subject><subject>Medical electronics</subject><subject>Muscles</subject><subject>Pain</subject><subject>Phase separation</subject><subject>poly(ethylene glycol)</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols</subject><subject>Prostheses and Implants</subject><subject>Skin</subject><subject>Stimulation</subject><subject>Stimulators</subject><subject>Stretchability</subject><subject>Surgical implants</subject><subject>Tissues</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLxDAQh4Mouj6uHqXgxUvXSR9pclzXxy4oCuq5pMlUK-lGkxbpf2_WXVfw4mUe8M2P4SPkmMKYAiTnUrdynADlALngW2RE84TGGYh8m4xApHksWMb3yL73bwAgGLBdspeIghaF4CPy-ODsi5NtKyuD0WzQYUUTze2iUdG0capvOh_V1kUXjTX2pVHSmCG6k516RR1dGVSd-4bniw5dLRX6Q7JTS-PxaN0PyPP11dN0Ft_e38ynk9tYZQXjcVWjAK0ZqvCz0lldg1RaFKnAJIy0KnJWyUwCaiUh0YInNBReF0rriqn0gJytct-d_ejRd2XbeIXGyAXa3pcJpGnKIQUW0NM_6Jvt3SJ8F6g8D4q4gECNV5Ry1nuHdfnumla6oaRQLnWXS93lRnc4OFnH9lWLeoP_-A2AWAGfjcHhn7hycnk3-Q3_AnjkjRk</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Zhao, Siwei</creator><creator>Tseng, Peter</creator><creator>Grasman, Jonathan</creator><creator>Wang, Yu</creator><creator>Li, Wenyi</creator><creator>Napier, Bradley</creator><creator>Yavuz, Burcin</creator><creator>Chen, Ying</creator><creator>Howell, Laurel</creator><creator>Rincon, Javier</creator><creator>Omenetto, Fiorenzo G.</creator><creator>Kaplan, David L.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9245-7774</orcidid></search><sort><creationdate>201806</creationdate><title>Programmable Hydrogel Ionic Circuits for Biologically Matched Electronic Interfaces</title><author>Zhao, Siwei ; Tseng, Peter ; Grasman, Jonathan ; Wang, Yu ; Li, Wenyi ; Napier, Bradley ; Yavuz, Burcin ; Chen, Ying ; Howell, Laurel ; Rincon, Javier ; Omenetto, Fiorenzo G. ; Kaplan, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4768-bfe90dd6ec152cd4ff0acd9739e2f0a1b756ba4a0edca02d9821d988f7cddb6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>aqueous two‐phase systems</topic><topic>Biocompatible Materials</topic><topic>Bioelectricity</topic><topic>bioelectronics</topic><topic>Circuits</topic><topic>Electric power distribution</topic><topic>Electrical resistivity</topic><topic>Electronic systems</topic><topic>Electronics</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>ionic circuits</topic><topic>Ions</topic><topic>Light emitting diodes</topic><topic>Medical devices</topic><topic>Medical electronics</topic><topic>Muscles</topic><topic>Pain</topic><topic>Phase separation</topic><topic>poly(ethylene glycol)</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols</topic><topic>Prostheses and Implants</topic><topic>Skin</topic><topic>Stimulation</topic><topic>Stimulators</topic><topic>Stretchability</topic><topic>Surgical implants</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Siwei</creatorcontrib><creatorcontrib>Tseng, Peter</creatorcontrib><creatorcontrib>Grasman, Jonathan</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Li, Wenyi</creatorcontrib><creatorcontrib>Napier, Bradley</creatorcontrib><creatorcontrib>Yavuz, Burcin</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Howell, Laurel</creatorcontrib><creatorcontrib>Rincon, Javier</creatorcontrib><creatorcontrib>Omenetto, Fiorenzo G.</creatorcontrib><creatorcontrib>Kaplan, David L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Siwei</au><au>Tseng, Peter</au><au>Grasman, Jonathan</au><au>Wang, Yu</au><au>Li, Wenyi</au><au>Napier, Bradley</au><au>Yavuz, Burcin</au><au>Chen, Ying</au><au>Howell, Laurel</au><au>Rincon, Javier</au><au>Omenetto, Fiorenzo G.</au><au>Kaplan, David L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Programmable Hydrogel Ionic Circuits for Biologically Matched Electronic Interfaces</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv Mater</addtitle><date>2018-06</date><risdate>2018</risdate><volume>30</volume><issue>25</issue><spage>e1800598</spage><epage>n/a</epage><pages>e1800598-n/a</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><abstract>The increased need for wearable and implantable medical devices has driven the demand for electronics that interface with living systems. Current bioelectronic systems have not fully resolved mismatches between engineered circuits and biological systems, including the resulting pain and damage to biological tissues. Here, salt/poly(ethylene glycol) (PEG) aqueous two‐phase systems are utilized to generate programmable hydrogel ionic circuits. High‐conductivity salt‐solution patterns are stably encapsulated within PEG hydrogel matrices using salt/PEG phase separation, which route ionic current with high resolution and enable localized delivery of electrical stimulation. This strategy allows designer electronics that match biological systems, including transparency, stretchability, complete aqueous‐based connective interface, distribution of ionic electrical signals between engineered and biological systems, and avoidance of tissue damage from electrical stimulation. The potential of such systems is demonstrated by generating light‐emitting diode (LED)‐based displays, skin‐mounted electronics, and stimulators that deliver localized current to in vitro neuron cultures and muscles in vivo with reduced adverse effects. Such electronic platforms may form the basis of future biointegrated electronic systems.
Programmable hydrogel ionic circuits completely composed of salt, water, and biofriendly hydrogels are developed based on salt/poly(ethylene glycol) aqueous two‐phase systems. Such systems enable designer electronics that match the properties of biological systems and route high‐resolution ionic electrical signals between engineered and living systems while avoiding tissue damage. Such platforms may form the basis of future biointegrated electronic systems.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29717798</pmid><doi>10.1002/adma.201800598</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9245-7774</orcidid></addata></record> |
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| subjects | aqueous two‐phase systems Biocompatible Materials Bioelectricity bioelectronics Circuits Electric power distribution Electrical resistivity Electronic systems Electronics Hydrogel, Polyethylene Glycol Dimethacrylate Hydrogels Hydrogels - chemistry ionic circuits Ions Light emitting diodes Medical devices Medical electronics Muscles Pain Phase separation poly(ethylene glycol) Polyethylene glycol Polyethylene Glycols Prostheses and Implants Skin Stimulation Stimulators Stretchability Surgical implants Tissues |
| title | Programmable Hydrogel Ionic Circuits for Biologically Matched Electronic Interfaces |
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