Synthesis of Isotopically Labeled (E)-β,γ-Unsaturated Esters with Total or High Diastereoselectivity by Using Samarium Diiodide

A simple, efficient, highly diastereoselective method for preparing (E)‐α,δ‐dideuterio‐β,γ‐unsaturated esters: SmI2‐promoted reduction/elimination of α‐halo‐β‐hydroxy‐γ,δ‐unsaturated esters in the presence of D2O (see scheme). This provides the desired products in which the C−C double bond is genera...

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Veröffentlicht in:	Angewandte Chemie International Edition 2001-10, Vol.40 (20), p.3897-3899
Hauptverfasser:	Concellón, José M., Bernad, Pablo L., Rodríguez-Solla, Humberto
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric synthesis deuterium elimination reduction samarium
Online-Zugang:	Volltext
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