Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis

No less than 30 stereogenic elements, a highly unsaturated 20‐membered macrocyclic system, four carbohydrate units, and unique biological activity, make the natural occurring apoptolidin (1) a challenging synthetic target. The retrosynthetic analysis revealed five key building blocks—three for the c...

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Veröffentlicht in:	Angewandte Chemie International Edition 2001-10, Vol.40 (20), p.3854-3857
Hauptverfasser:	Nicolaou, K. C., Li, Yiwei, Fylaktakidou, Konstantina C., Mitchell, Helen J., Sugita, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptolidin macrolides natural products total synthesis
Online-Zugang:	Volltext
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