Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei

Six building blocks, six reaction steps: The recently developed innovative methodology facilitated the convergent synthesis of the complex oligosaccharide core 1 (shown here with protecting groups) for the total synthesis of a glycosylphosphatidylinositol (GPI) anchor. The key factors are the tuning...

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Veröffentlicht in:	Angewandte Chemie International Edition 1998-12, Vol.37 (24), p.3423-3428
Hauptverfasser:	Baeschlin, Daniel K., Chaperon, André R., Charbonneau, Virginie, Green, Luke G., Ley, Steven V., Lücking, Ulrich, Walther, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals Glycosylations Inositolphosphates Oligosaccharides Protecting groups Trypanosoma brucei
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creator	Baeschlin, Daniel K. Chaperon, André R. Charbonneau, Virginie Green, Luke G. Ley, Steven V. Lücking, Ulrich Walther, Eric
description	Six building blocks, six reaction steps: The recently developed innovative methodology facilitated the convergent synthesis of the complex oligosaccharide core 1 (shown here with protecting groups) for the total synthesis of a glycosylphosphatidylinositol (GPI) anchor. The key factors are the tuning of the reactivity of the building blocks by using 1,2‐diacetal protecting groups and the desymmetrization of glycerol and myo‐inositol with a chiral bis(dihydropyran).
doi_str_mv	10.1002/(SICI)1521-3773(19981231)37:24<3423::AID-ANIE3423>3.0.CO;2-I
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subjects	Acetals Glycosylations Inositolphosphates Oligosaccharides Protecting groups Trypanosoma brucei
title	Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei
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