Macrocyclic Cyclopropenes by Highly Enantioselective Intramolecular Addition of Metal Carbenes to Alkynes

The intramolecular addition of a diazo ester group to a triple bond in the presence of chiral dirhodium(II) carboxamidate catalysts gives macrocyclic lactones with a fused cycloproprene ring [Eq. (a)]. This efficient reaction is characterized by high enantiocontrol (up to 98% ee) and chemoselectivit...

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Veröffentlicht in:	Angewandte Chemie International Edition 1999-03, Vol.38 (5), p.700-702
Hauptverfasser:	Doyle, Michael P., Ene, Doina G., Peterson, Chad S., Lynch, Vince
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric synthesis Carbene complexes Homogeneous catalysis Macrocycles Rhodium
Online-Zugang:	Volltext
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