Chronic pancreatitis and resectable synchronous pancreatic carcinoma: A survival analysis
: Chronic pancreatitis (CP) is a risk factor for pancreatic cancer (PDAC). CP and PDAC are characterized by an abundance of desmoplastic tissue. The effect of this pancreatic desmoplastic tissue on PDAC is poorly understood. In literature, negative and positive effects on the natural course of PDAC...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2018-06, Vol.18 (4), p.394-398 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
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| creator | Birgin, Emrullah Hablawetz, Patrick Téoule, Patrick Rückert, Felix Wilhelm, Torsten J. |
| description | : Chronic pancreatitis (CP) is a risk factor for pancreatic cancer (PDAC). CP and PDAC are characterized by an abundance of desmoplastic tissue. The effect of this pancreatic desmoplastic tissue on PDAC is poorly understood. In literature, negative and positive effects on the natural course of PDAC have been discussed. The present analysis aims to assess the impact of CP on patients with resectable synchronous PDAC regarding short- and long-term survival.
: All patients who underwent pancreatic resection at our institution from January 2005 to January 2014 were retrospectively evaluated. Definition of CP was based on clinical and radiological aspects and histological confirmation as used previously. We identified patients with CP, CP and PDAC, and PDAC without CP and compared perioperative course and survival. Statistical analysis was performed by chi-square, Kruskal-Wallis/Mann-Whitney-U and Breslow survival analysis. P-values |
| doi_str_mv | 10.1016/j.pan.2018.04.009 |
| format | Article |
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: All patients who underwent pancreatic resection at our institution from January 2005 to January 2014 were retrospectively evaluated. Definition of CP was based on clinical and radiological aspects and histological confirmation as used previously. We identified patients with CP, CP and PDAC, and PDAC without CP and compared perioperative course and survival. Statistical analysis was performed by chi-square, Kruskal-Wallis/Mann-Whitney-U and Breslow survival analysis. P-values <0.05 were defined as statistically significant.
: 159 patients met our inclusion criteria for CP. 49 of them (30.8%) had synchronous PDAC. 145 patients had PDAC without a history of CP. There was a more advanced nodal involvement in PDAC patients with CP. Perioperative outcome and long-term survival of PDAC patients with and without CP did not differ significantly.
: In a large clinical series CP had no impact on survival of patients with PDAC after resection with curative intent.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2018.04.009</identifier><identifier>PMID: 29716797</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Aged ; Alcohol ; Body mass index ; Cardiovascular disease ; Chemotherapy ; Chronic pancreatitis ; Combined Modality Therapy ; Desmoplastic stroma ; Diabetes ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Pancreas - pathology ; Pancreatectomy ; Pancreatic cancer ; Pancreatic carcinoma ; Pancreatic Neoplasms ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Pancreatitis ; Pancreatitis, Chronic - mortality ; Pancreatitis, Chronic - pathology ; Pancreatitis, Chronic - surgery ; Patients ; Retrospective Studies ; Risk Factors ; Statistical analysis ; Surgery ; Survival ; Survival Analysis ; Synchronous pancreatic cancer ; Treatment Outcome ; Tumors</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2018-06, Vol.18 (4), p.394-398</ispartof><rights>2018 IAP and EPC</rights><rights>Copyright © 2018 IAP and EPC. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-76c40e14b011662d26d9a57f4fb136f5efd740f46b0530cfbdb0c24d7c416f9d3</citedby><cites>FETCH-LOGICAL-c381t-76c40e14b011662d26d9a57f4fb136f5efd740f46b0530cfbdb0c24d7c416f9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29716797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Birgin, Emrullah</creatorcontrib><creatorcontrib>Hablawetz, Patrick</creatorcontrib><creatorcontrib>Téoule, Patrick</creatorcontrib><creatorcontrib>Rückert, Felix</creatorcontrib><creatorcontrib>Wilhelm, Torsten J.</creatorcontrib><title>Chronic pancreatitis and resectable synchronous pancreatic carcinoma: A survival analysis</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>: Chronic pancreatitis (CP) is a risk factor for pancreatic cancer (PDAC). CP and PDAC are characterized by an abundance of desmoplastic tissue. The effect of this pancreatic desmoplastic tissue on PDAC is poorly understood. In literature, negative and positive effects on the natural course of PDAC have been discussed. The present analysis aims to assess the impact of CP on patients with resectable synchronous PDAC regarding short- and long-term survival.
: All patients who underwent pancreatic resection at our institution from January 2005 to January 2014 were retrospectively evaluated. Definition of CP was based on clinical and radiological aspects and histological confirmation as used previously. We identified patients with CP, CP and PDAC, and PDAC without CP and compared perioperative course and survival. Statistical analysis was performed by chi-square, Kruskal-Wallis/Mann-Whitney-U and Breslow survival analysis. P-values <0.05 were defined as statistically significant.
: 159 patients met our inclusion criteria for CP. 49 of them (30.8%) had synchronous PDAC. 145 patients had PDAC without a history of CP. There was a more advanced nodal involvement in PDAC patients with CP. Perioperative outcome and long-term survival of PDAC patients with and without CP did not differ significantly.
: In a large clinical series CP had no impact on survival of patients with PDAC after resection with curative intent.</description><subject>Aged</subject><subject>Alcohol</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Chemotherapy</subject><subject>Chronic pancreatitis</subject><subject>Combined Modality Therapy</subject><subject>Desmoplastic stroma</subject><subject>Diabetes</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreas - pathology</subject><subject>Pancreatectomy</subject><subject>Pancreatic cancer</subject><subject>Pancreatic carcinoma</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreatitis</subject><subject>Pancreatitis, Chronic - mortality</subject><subject>Pancreatitis, Chronic - pathology</subject><subject>Pancreatitis, Chronic - surgery</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Synchronous pancreatic cancer</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMovn-AGxlw46bjvUmadHRVii8Q3OjCVcjkgSnTmZrMFPrvTakPcOHq3sV3DoePkDOEEgHF1bxc6rakgJMSeAlQ7ZBD5JSPWIW4-_MDOyBHKc0BKEWs9skBrSQKWclD8jZ7j10bTJGbTHS6D31IhW5tEV1yptd144q0bs0G64b0y5nC6GhC2y30dTEt0hBXYaWbnNXNOoV0Qva8bpI7_brH5PXu9mX2MHp6vn-cTZ9Ghk2wH0lhODjkNSAKQS0VttJj6bmvkQk_dt5KDp6LGsYMjK9tDYZyKw1H4SvLjsnltncZu4_BpV4tQjKuaXTr8mBFgTEmhaQioxd_0Hk3xLx3Q42BS5hQzBRuKRO7lKLzahnDQse1QlAb72qusgW18a6Aq-w9Z86_mod64exP4lt0Bm62gMsqVsFFlUxwrXE2xKxZ2S78U_8JVsuTfA</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Birgin, Emrullah</creator><creator>Hablawetz, Patrick</creator><creator>Téoule, Patrick</creator><creator>Rückert, Felix</creator><creator>Wilhelm, Torsten J.</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>Chronic pancreatitis and resectable synchronous pancreatic carcinoma: A survival analysis</title><author>Birgin, Emrullah ; 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[et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Birgin, Emrullah</au><au>Hablawetz, Patrick</au><au>Téoule, Patrick</au><au>Rückert, Felix</au><au>Wilhelm, Torsten J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic pancreatitis and resectable synchronous pancreatic carcinoma: A survival analysis</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2018-06</date><risdate>2018</risdate><volume>18</volume><issue>4</issue><spage>394</spage><epage>398</epage><pages>394-398</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>: Chronic pancreatitis (CP) is a risk factor for pancreatic cancer (PDAC). CP and PDAC are characterized by an abundance of desmoplastic tissue. The effect of this pancreatic desmoplastic tissue on PDAC is poorly understood. In literature, negative and positive effects on the natural course of PDAC have been discussed. The present analysis aims to assess the impact of CP on patients with resectable synchronous PDAC regarding short- and long-term survival.
: All patients who underwent pancreatic resection at our institution from January 2005 to January 2014 were retrospectively evaluated. Definition of CP was based on clinical and radiological aspects and histological confirmation as used previously. We identified patients with CP, CP and PDAC, and PDAC without CP and compared perioperative course and survival. Statistical analysis was performed by chi-square, Kruskal-Wallis/Mann-Whitney-U and Breslow survival analysis. P-values <0.05 were defined as statistically significant.
: 159 patients met our inclusion criteria for CP. 49 of them (30.8%) had synchronous PDAC. 145 patients had PDAC without a history of CP. There was a more advanced nodal involvement in PDAC patients with CP. Perioperative outcome and long-term survival of PDAC patients with and without CP did not differ significantly.
: In a large clinical series CP had no impact on survival of patients with PDAC after resection with curative intent.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>29716797</pmid><doi>10.1016/j.pan.2018.04.009</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Alcohol Body mass index Cardiovascular disease Chemotherapy Chronic pancreatitis Combined Modality Therapy Desmoplastic stroma Diabetes Female Humans Hypertension Male Middle Aged Pancreas - pathology Pancreatectomy Pancreatic cancer Pancreatic carcinoma Pancreatic Neoplasms Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreatitis Pancreatitis, Chronic - mortality Pancreatitis, Chronic - pathology Pancreatitis, Chronic - surgery Patients Retrospective Studies Risk Factors Statistical analysis Surgery Survival Survival Analysis Synchronous pancreatic cancer Treatment Outcome Tumors |
| title | Chronic pancreatitis and resectable synchronous pancreatic carcinoma: A survival analysis |
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